Rabbit Anti-TSPAN6 Polyclonal Antibody – Cat# MBS6359619

TSPAN6 Antibody – Rabbit Polyclonal

Name: TSPAN6 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6359619
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6359619

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TSPAN6, Polyclonal Antibody

Full Product Name

TSPAN6, CT (TSPAN6, TM4SF6, Tetraspanin-6, A15 homolog, Putative NF-kappa-B-activating protein 321, T245 protein, Tetraspanin TM4-D, Transmembrane 4 superfamily member 6) (Biotin)

Product Gene Name

anti-TSPAN6 antibody

Product Synonym Names

TSPAN6; TM4SF6; Tetraspanin-6; A15 homolog; Putative NF-kappa-B-activating protein 321; T245 protein; Tetraspanin TM4-D; Transmembrane 4 superfamily member 6

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

27,563 Da

OMIM

300191

3D Structure

ModBase 3D Structure for O43657

Immunogen

TSPAN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-177 amino acids from the C-terminal region of human TSPAN6.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-TSPAN6 antibody

Antibodies; Tetraspanin

Applications Tested/Suitable for anti-TSPAN6 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-TSPAN6 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-TSPAN6 antibody

Ross, M.T., et al. Nature 434(7031):325-337(2005). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003). Matsuda, A., et al. Oncogene 22(21):3307-3318(2003). Berditchevski, F. J. Cell. Sci. 114 (PT 23), 4143-4151 (2001): Maeda, K., et al. Genomics 52(2):240-242(1998).

Other Notes

Small volumes of anti-TSPAN6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSPAN6 purchase

MBS6359619 is an antibody targeting TSPAN6. Also known as TSPAN6, CT (TSPAN6, TM4SF6, Tetraspanin-6, A15 homolog, Putative NF-kappa-B-activating protein 321, T245 protein, Tetraspanin TM4-D, Transmembrane 4 superfamily member 6) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TSPAN6. It may not necessarily be applicable to this product.

NCBI GI #

4507541

NCBI GeneID

7105

NCBI Accession #

NP_003261.1

UniProt Primary Accession #

O43657

UniProt Secondary Accession #

Q54A42; Q6IAN9

UniProt Related Accession #

O43657

GenBank Nucleotide #

NM_003270.3

NCBI Official Full Name

tetraspanin-6 isoform a

NCBI Official Synonym Full Names

tetraspanin 6

NCBI Official Symbol

TSPAN6

NCBI Official Synonym Symbols

T245; TM4SF6; TSPAN-6

UniProt Protein Name

Tetraspanin-6

UniProt Synonym Protein Names

A15 homolog; Putative NF-kappa-B-activating protein 321; T245 protein; Tetraspanin TM4-D; Transmembrane 4 superfamily member 6

UniProt Gene Name

TSPAN6

UniProt Synonym Gene Names

TM4SF6; Tspan-6

UniProt Entry Name

TSN6_HUMAN

NCBI Protein Information

tetraspanin-6; A15 homolog; tetraspan TM4SF; tetraspanin TM4-D; transmembrane 4 superfamily member 6; putative NF-kappa-B-activating protein 321

NCBI Summary for TSPAN6

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]

UniProt Comments for TSPAN6

TSPAN6: is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: integral to membrane

Molecular Function: protein binding; signal transducer activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction

Research Articles on TSPAN6

1. TSPAN6 functions as a negative regulator of the RLR pathway by interacting with MAVS in a ubiquitination-dependent manner.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TSPAN6 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>1 publications with TSPAN6 and Congenital Abnormalities
Abnormalities, Multiple Antibodies	>1 publications with TSPAN6 and Abnormalities, Multiple

Organs/Tissues associated with anti-TSPAN6 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with TSPAN6 and Brain
Pancreas Antibodies	>1 publications with TSPAN6 and Pancreas
Muscle Antibodies	>1 publications with TSPAN6 and Muscle
Ovary Antibodies	>1 publications with TSPAN6 and Ovary
Liver Antibodies	>1 publications with TSPAN6 and Liver
Lung Antibodies	>1 publications with TSPAN6 and Lung
Kidney Antibodies	>1 publications with TSPAN6 and Kidney