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TTF2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8101267

Papillary thyroid cancer (PTC), one of the most common malignant thyroid tumors, exits widely in the thyroid of adolescents. Thyroid transcription factor 1 (TTF1) and 2 (TTF2) were thyroid-specific transcription factors, and regulated expression of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
TTF2, Polyclonal Antibody
Full Product Name
Anti-TTF2 Antibody, Rabbit Polyclonal
Product Gene Name
anti-TTF2 antibody
Product Synonym Names
TTF2 Antibody, Rabbit PAb, Antigen Affinity Purified; Anti-HuF2 Antibody
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid; 0.2um filtered solution in PBS
Purity/Purification
Protein A & Antigen Affinity
Specificity
Human TTF2
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Molecular Weight
129,588 Da
OMIM
604718
3D Structure
ModBase 3D Structure for Q9UNY4
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human TTF2
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human TTF2, and purified by antigen affinity chromatography.
Applications Tested/Suitable for anti-TTF2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-TTF2 antibody
WB: 1:500-1:1000
IP: 1-2uL/mg of lysate

Western Blot (WB) of anti-TTF2 antibody

Anti-TTF2 rabbit polyclonal antibody at 1:500 dilution
Lane A: Jurkat Whole Cell Lysate

Lysates/proteins at 30 ug per lane.
Secondary
Goat Anti- Rabbit  IgG H&L (Dylight 800)  at 1/10000 dilution.

Developed using the Odyssey technique.
Performed under reducing conditions.

Predicted band size:130 kDa
Observed band size:145 kDa
Rabbit Anti-TTF2 Polyclonal Antibody – Cat# MBS8101267

Immunoprecipitation (IP) of anti-TTF2 antibody

TTF2 was immunoprecipitated using:
Lane A:0.5 mg Hela Whole Cell Lysate

1 uL anti-TTF2 rabbit polyclonal antibody and 15 ul of 50 % Protein G agarose.

Primary antibody:
Anti-TTF2 rabbit polyclonal antibody,at 1:500 dilution

Secondary antibody:
Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.
Performed under reducing conditions.

Predicted band size: 127 kDa
Observed band size: 127 kDa
Rabbit Anti-TTF2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS8101267

Other Notes

Small volumes of anti-TTF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TTF2 purchase

MBS8101267 is an antibody targeting TTF2. Also known as Anti-TTF2 Antibody, Rabbit Polyclonal. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TTF2. It may not necessarily be applicable to this product.

NCBI GI #
119577071
NCBI GeneID
8458
NCBI Accession #
EAW56667.1
UniProt Primary Accession #
Q9UNY4
UniProt Secondary Accession #
O75921; Q5T2K7; Q5VVU8; Q8N6I8; A8K4Q2
UniProt Related Accession #
Q9UNY4
NCBI Official Full Name
transcription termination factor, RNA polymerase II, isoform CRA_a
NCBI Official Synonym Full Names
transcription termination factor, RNA polymerase II
NCBI Official Symbol
TTF2
NCBI Official Synonym Symbols
HuF2; ZGRF6
UniProt Protein Name
Transcription termination factor 2
UniProt Synonym Protein Names
Lodestar homolog; RNA polymerase II termination factor; Transcription release factor 2
Protein Family
Transcription termination factor
UniProt Gene Name
TTF2
UniProt Synonym Gene Names
F2; HuF2
UniProt Entry Name
TTF2_HUMAN
NCBI Protein Information
transcription termination factor 2; F2; human factor 2; lodestar homolog; lodestar protein; transcription release factor 2; zinc finger, GRF-type containing 6; RNA polymerase II termination factor

NCBI Summary for TTF2

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. [provided by RefSeq, Jul 2008]
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UniProt Comments for TTF2

TTF2: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Helicase; EC 3.6.4.-; Transcription regulation; EC 3.6.1.-; RNA splicing; DNA-binding

Chromosomal Location of Human Ortholog: 1p22

Cellular Component: spliceosome; transcription elongation factor complex; cytoplasm

Molecular Function: DNA-dependent ATPase activity; protein binding; DNA binding; zinc ion binding; ATP-dependent helicase activity; ATP binding

Biological Process: regulation of transcription, DNA-dependent; RNA splicing; mRNA processing; termination of RNA polymerase II transcription; transcription termination
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Research Articles on TTF2

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TTF2 antibody

 Reference Product  PubMed Publications
 CDK9 antibody  >1 publications with TTF2 and CDK9

Pathways associated with anti-TTF2 antibody

 Products by Pathway  Pathway Diagram
 TSH Signaling Pathway antibodies  TSH Signaling Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram

Diseases associated with anti-TTF2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with TTF2 and Nervous System Diseases
 Memory Disorders Antibodies  >1 publications with TTF2 and Memory Disorders
 Breast Neoplasms Antibodies  >1 publications with TTF2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with TTF2 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >1 publications with TTF2 and Ovarian Neoplasms
 Hyperplasia Antibodies  >1 publications with TTF2 and Hyperplasia
 Hypertension Antibodies  >1 publications with TTF2 and Hypertension
 Kidney Diseases Antibodies  >1 publications with TTF2 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with TTF2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-TTF2 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >24 publications with TTF2 and Thyroid
 Skin Antibodies  >4 publications with TTF2 and Skin
 Blood Antibodies  >4 publications with TTF2 and Blood
 Bone Antibodies  >3 publications with TTF2 and Bone
 Connective Tissue Antibodies  >2 publications with TTF2 and Connective Tissue
 Vascular Antibodies  >2 publications with TTF2 and Vascular
 Muscle Antibodies  >2 publications with TTF2 and Muscle
 Prostate Antibodies  >1 publications with TTF2 and Prostate
 Pancreas Antibodies  >1 publications with TTF2 and Pancreas
 Kidney Antibodies  >1 publications with TTF2 and Kidney
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