TYK2 Antibody – Rabbit Polyclonal

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

1. Ragimbeau, J., et al., EMBO J. 22(3):537-547 (2003). 2. Trask, B., et al., Genomics 15(1):133-145 (1993). 3. Firmbach-Kraft, I., et al., Oncogene 5(9):1329-1336 (1990). 4. Krolewski, J.J., et al., Oncogene 5(3):277-282 (1990).

Small volumes of anti-TYK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6504242 is an antibody targeting TYK2. Also known as TYK2, CT (Non-receptor Tyrosine-protein Kinase TYK2) (Azide free) (HRP). Reactive in Human. Host: Rabbit.