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Tyrosinase (TYR) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9415662

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6… More details

$370 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Tyrosinase, Polyclonal Antibody
Full Product Name
Tyrosinase Polyclonal Antibody
Product Gene Name
anti-TYR antibody
Product Synonym Names
LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB; TYR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total Tyrosinase polyclonal antibody.
Preparation and Storage
Store at -20 degree C
Molecular Weight
42,914 Da
OMIM
103470
3D Structure
ModBase 3D Structure for P14679
Immunogen
Recombinant Human Tyrosinase protein£¨19-377aa£©
Immunogen Type
Protein

Product Categories/Family for anti-TYR antibody

Total protein Ab
Applications Tested/Suitable for anti-TYR antibody
Immunohistochemistry (IHC)
Application Notes for anti-TYR antibody
Immunohistochemistry: 1:20 - 1:200

Immunohistochemistry (IHC) of anti-TYR antibody

Immunohistochemical analysis of paraffin-embedded human skin using at dilution of 1:100.
Rabbit Anti-TYR Polyclonal Antibody – Cat# MBS9415662

Other Notes

Small volumes of anti-TYR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TYR purchase

MBS9415662 is an antibody targeting TYR. Also known as Tyrosinase Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TYR. It may not necessarily be applicable to this product.

NCBI GI #
4507753
NCBI GeneID
7299
NCBI Accession #
NP_000363.1
UniProt Primary Accession #
P14679
UniProt Secondary Accession #
Q15675; Q15676; Q15680; Q8TAK4; Q9BYY0; Q9BZX1
UniProt Related Accession #
P14679
GenBank Nucleotide #
NM_000372.4
NCBI Official Full Name
tyrosinase
NCBI Official Synonym Full Names
tyrosinase
NCBI Official Symbol
TYR
NCBI Official Synonym Symbols
ATN; CMM8; OCA1; OCA1A; OCAIA; SHEP3
UniProt Protein Name
Tyrosinase
UniProt Synonym Protein Names
LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB
Protein Family
Tyrosinase
UniProt Gene Name
TYR
UniProt Entry Name
TYRO_HUMAN
NCBI Protein Information
tyrosinase

UniProt Comments for TYR

TYR: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - riboflavin; EC 1.14.18.1; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: cytoplasm; Golgi-associated vesicle; lysosome; melanosome; melanosome membrane; perinuclear region of cytoplasm

Molecular Function: copper ion binding; monooxygenase activity; monophenol monooxygenase activity; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: eye pigment biosynthetic process; melanin biosynthetic process; melanin biosynthetic process from tyrosine; visual perception

Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ia; Albinism, Oculocutaneous, Type Ib; Skin/hair/eye Pigmentation, Variation In, 3
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TYR antibody

 Reference Product  PubMed Publications
 TAT antibody  >100 publications with TYR and TAT
 PAH antibody  >59 publications with TYR and PAH
 PMEL antibody  >17 publications with TYR and PMEL
 MLANA antibody  >17 publications with TYR and MLANA
 TPO antibody  >10 publications with TYR and TPO
 GOT1 antibody  >5 publications with TYR and GOT1
 DDC antibody  >5 publications with TYR and DDC

Pathways associated with anti-TYR antibody

 Products by Pathway  Pathway Diagram
 (S)-reticuline Biosynthesis Pathway antibodies  (S)-reticuline Biosynthesis Pathway Diagram
 (S)-reticuline Biosynthesis II Pathway antibodies  (S)-reticuline Biosynthesis II Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Dopamine Metabolism Pathway antibodies  Dopamine Metabolism Pathway Diagram
 L-dopachrome Biosynthesis Pathway antibodies  L-dopachrome Biosynthesis Pathway Diagram
 L-dopachrome Biosynthesis Pathway antibodies  L-dopachrome Biosynthesis Pathway Diagram
 Melanin Biosynthesis Pathway antibodies  Melanin Biosynthesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram

Diseases associated with anti-TYR antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >851 publications with TYR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >441 publications with TYR and Cardiovascular Diseases
 Pain Antibodies  >427 publications with TYR and Pain
 Inflammation Antibodies  >416 publications with TYR and Inflammation
 Melanoma Antibodies  >366 publications with TYR and Melanoma
 Neoplasms, Experimental Antibodies  >283 publications with TYR and Neoplasms, Experimental
 Liver Diseases Antibodies  >231 publications with TYR and Liver Diseases
 Necrosis Antibodies  >225 publications with TYR and Necrosis
 Hypertension Antibodies  >214 publications with TYR and Hypertension
 Kidney Diseases Antibodies  >185 publications with TYR and Kidney Diseases

Organs/Tissues associated with anti-TYR antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >566 publications with TYR and Skin
 Eye Antibodies  >294 publications with TYR and Eye
 Thyroid Antibodies  >187 publications with TYR and Thyroid
 Connective Tissue Antibodies  >140 publications with TYR and Connective Tissue
 Mammary Gland Antibodies  >42 publications with TYR and Mammary Gland
 Ear Antibodies  >31 publications with TYR and Ear
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