• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

UBP46 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6360959

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UBP46, Polyclonal Antibody
Full Product Name
UBP46, CT (USP46, Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46) (AP)
Product Gene Name
anti-UBP46 antibody
Product Synonym Gene Name
USP46
Product Synonym Names
USP46; Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
41,112 Da
OMIM
612849
3D Structure
ModBase 3D Structure for P62068
Immunogen
UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the C-terminal region of human UBP46.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-UBP46 antibody

Antibodies; Ubiquitin
Applications Tested/Suitable for anti-UBP46 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-UBP46 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-UBP46 antibody

UBP46 Antibody (C-term) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the UBP46 antibody detected the UBP46 protein (arrow).
Rabbit Anti-UBP46 Polyclonal Antibody – Cat# MBS6360959

Product References and Citations for anti-UBP46 antibody

Kushima, I., et al. J. Hum. Genet. 55(3):133-136(2010). Cohn, M.A., et al. J. Biol. Chem. 284(8):5343-5351(2009). Zemunik, T., et al. Croat. Med. J. 50(1):23-33(2009). Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004). Puente, X.S., et al. Nat. Rev. Genet. 4(7):544-558(2003).

Other Notes

Small volumes of anti-UBP46 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBP46 purchase

MBS6360959 is an antibody targeting UBP46. Also known as UBP46, CT (USP46, Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBP46. It may not necessarily be applicable to this product.

NCBI GI #
197116355
NCBI GeneID
64854
NCBI Accession #
NP_001127695.1
NCBI Related Accession #
NP_073743.2
UniProt Primary Accession #
P62068
UniProt Secondary Accession #
Q80V95; Q9H7U4; Q9H9T8; B7Z3Y7; B7Z675; B7Z7S3; G8ACC7
UniProt Related Accession #
P62068
GenBank Nucleotide #
NM_001134223.1
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 46 isoform 2
NCBI Official Synonym Full Names
ubiquitin specific peptidase 46
NCBI Official Symbol
USP46
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 46
UniProt Synonym Protein Names
Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
UniProt Gene Name
USP46
UniProt Entry Name
UBP46_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 46; deubiquitinating enzyme 46; ubiquitin thioesterase 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46

UniProt Comments for UBP46

USP46: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 4q12

Molecular Function: protein binding; ubiquitin-specific protease activity

Biological Process: ubiquitin-dependent protein catabolic process; behavioral fear response; protein deubiquitination; righting reflex; adult feeding behavior; behavioral response to ethanol; regulation of synaptic transmission, GABAergic
Show more

Research Articles on UBP46

1. USP46-mediated stabilization of PHLPP and the subsequent inhibition of Akt.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBP46 antibody

 Reference Product  PubMed Publications
 USP12 antibody  >4 publications with UBP46 and USP12
 WDR48 antibody  >2 publications with UBP46 and WDR48
 PHLPP1 antibody  >2 publications with UBP46 and PHLPP1
 WDR20 antibody  >2 publications with UBP46 and WDR20

Diseases associated with anti-UBP46 antibody

 Disease Name  Pubmed Publications
 Intestinal Neoplasms Antibodies  >2 publications with UBP46 and Intestinal Neoplasms

Organs/Tissues associated with anti-UBP46 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with UBP46 and Brain
 Skin Antibodies  >1 publications with UBP46 and Skin
 Spleen Antibodies  >1 publications with UBP46 and Spleen
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000