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UCMA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005027

May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. More details

$935 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UCMA, Polyclonal Antibody
Full Product Name
UCMA, CT (Unique Cartilage Matrix-associated Protein, C10orf49)
Product Gene Name
anti-UCMA antibody
Product Synonym Names
Anti -UCMA, CT (Unique Cartilage Matrix-associated Protein, C10orf49)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human UCMA. Species sequence homology: Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
16,563 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (13263771..13276331, complement). Location: 10p13
3D Structure
ModBase 3D Structure for Q8WVF2
Immunogen
Synthetic peptide corresponding to human UCMA at C-terminal conjugated to KLH.

Product Categories/Family for anti-UCMA antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-UCMA antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-UCMA antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 2.5-5ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-UCMA antibody

Human Lung, Chondrocytes: Formalin-Fixed, Paraffin- Embedded (FFPE)
Rabbit Anti-UCMA Polyclonal Antibody – Cat# MBS6005027

Western Blot (WB) of anti-UCMA antibody

Western blot analysis of UCMA in SW1353 cell lysate with UCMA antibody at (A) 2.5 and (B) 5ug/ml.
Rabbit Anti-UCMA Polyclonal Antibody, Western Blot (WB) – Cat# MBS6005027

Other Notes

Small volumes of anti-UCMA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UCMA purchase

MBS6005027 is an antibody targeting UCMA. Also known as UCMA, CT (Unique Cartilage Matrix-associated Protein, C10orf49). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UCMA. It may not necessarily be applicable to this product.

NCBI GI #
50400088
NCBI GeneID
221044
NCBI Accession #
NP_660357.2
UniProt Primary Accession #
Q8WVF2
UniProt Related Accession #
Q8WVF2
GenBank Nucleotide #
NM_145314.1
NCBI Official Full Name
unique cartilage matrix-associated protein
NCBI Official Synonym Full Names
upper zone of growth plate and cartilage matrix associated
NCBI Official Symbol
UCMA
NCBI Official Synonym Symbols
GRP; C10orf49
UniProt Protein Name
Unique cartilage matrix-associated protein
UniProt Synonym Protein Names
Gla-rich protein
Protein Family
Unique cartilage matrix-associated protein
UniProt Gene Name
UCMA
UniProt Synonym Gene Names
C10orf49; Ucma-C; GRP
UniProt Entry Name
UCMA_HUMAN
NCBI Protein Information
unique cartilage matrix-associated protein; Gla-rich protein

NCBI Summary for UCMA

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
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UniProt Comments for UCMA

UCMA: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: extracellular space; proteinaceous extracellular matrix; perinuclear region of cytoplasm

Biological Process: negative regulation of osteoblast differentiation
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Research Articles on UCMA

1. Gla-rich protein (GRP) is a new vitamin K-dependent protein that can bind calcium through Gla residues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-UCMA antibody

 Disease Name  Pubmed Publications
 Arthritis Antibodies  >1 publications with UCMA and Arthritis

Organs/Tissues associated with anti-UCMA antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >3 publications with UCMA and Connective Tissue
 Embryonic Tissue Antibodies  >3 publications with UCMA and Embryonic Tissue
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