UCN2 Antibody – Rabbit Polyclonal

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

UCN2: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: extracellular region; extracellular space

Molecular Function: corticotropin-releasing hormone receptor 2 binding; G-protein-coupled receptor binding; hormone activity; hormone binding; receptor binding

Biological Process: cAMP biosynthetic process; cell proliferation; cellular response to nutrient levels; digestion; G-protein signaling, adenylate cyclase activating pathway; negative regulation of follicle-stimulating hormone secretion; negative regulation of luteinizing hormone secretion; response to stress