UGP2 Antibody – Rabbit Polyclonal

Uridine diphosphate-glucose pyrophosphorylase 2 (UGP2), a key enzyme in glycogen biosynthesis, is associated with the occurrence and development of various cancer types. UDP-glucose (UDP-Glc) is synthesized by UGP2-encoded UDP-Glc pyrophosphorylase (UGP) and is required for glycoconjugate biosynthesis and galactose metabolism because it is a uridyl donor for galactose-1-P (Gal1P) uridyltransferase. Chinese hamster lung fibroblasts harboring a hypomrphic UGP(G116D) variant display reduced UDP-Glc levels and cannot grow if galactose is the sole carbon source. UGP2 may contribute to the progression of HCC, indicating a potential therapeutic target for HCC patients. The high content of UGP2 in Rendement Napole (RN) mutant animals may contribute to high glycogen storage. The rice (Oryza sativa) genome contains two homologous UDP-glucose pyrophosphorylase (UGPase) genes, Ugp1 and Ugp2.

Huang H, et al. (2018) Quantitative proteomics and phosphoproteomics analysis revealed different regulatory mechanisms of halothane and rendement napole genes in porcine muscle metabolism. J Proteome Res 17 (8): 2834-2849.Hu Q, et al. (2020) Low ugp2 expression is associated with tumour progression and predicts poor prognosis in hepatocellular carcinoma. Dis Markers 2020 3231273.Durrant C, et al. (2020) Defects in galactose metabolism and glycoconjugate biosynthesis in a udp-glucose pyrophosphorylase-deficient cell line are reversed by adding galactose to the growth medium. Int J Mol Sci 21 (6): 2028.Chen R, et al. (2007) Rice udp-glucose pyrophosphorylase1 is essential for pollen callose deposition and its cosuppression results in a new type of thermosensitive genic male sterility. Plant Cell 19 (3): 847-861.

Small volumes of anti-UGP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8109619 is an antibody targeting UGP2. Also known as Anti-UGP2 Antibody, Rabbit Polyclonal. Reactive in Human. Host: Rabbit.