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UGT2B15 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6361189

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067). More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UGT2B15, Polyclonal Antibody
Full Product Name
UGT2B15, ID (UGT2B15, UGT2B8, UDP-glucuronosyltransferase 2B15, HLUG4, UDP-glucuronosyltransferase 2B8, UDPGTh-3) (PE)
Product Gene Name
anti-UGT2B15 antibody
Product Synonym Names
UGT2B15; UGT2B8; UDP-glucuronosyltransferase 2B15; HLUG4; UDP-glucuronosyltransferase 2B8; UDPGTh-3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
61,036 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (69512315..69536494, complement). Location: 4q13
OMIM
600069
3D Structure
ModBase 3D Structure for P54855
Immunogen
UGT2B15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-193 amino acids from the Central region of human UGT2B15.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-UGT2B15 antibody

Antibodies; Enzymes; Glucuronosyltransferase
Applications Tested/Suitable for anti-UGT2B15 antibody
Flow Cytometry (FC/FACS), FLISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-UGT2B15 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IF: 1:10-50
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-UGT2B15 antibody

UGT2B15 Antibody (Center) western blot analysis in NCI-H460(lane 1),HepG2(lane 2),ZR-75-1(lane 3) cell line lysates (35ug/lane).This demonstrates the UGT2B15 antibody detected the UGT2B15 protein (arrow).
Rabbit Anti-UGT2B15 Polyclonal Antibody – Cat# MBS6361189

Immunohistochemistry (IHC) of anti-UGT2B15 antibody

UGT2B15 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Rabbit Anti-UGT2B15 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6361189

Immunofluorescence (IF) of anti-UGT2B15 antibody

Confocal immunofluorescent analysis of UGT2B15 Antibody (Center) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-UGT2B15 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6361189

Flow Cytometry (FC/FACS) of anti-UGT2B15 antibody

UGT2B15 Antibody (Center) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-UGT2B15 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6361189

Product References and Citations for anti-UGT2B15 antibody

Yong, M., et al. Cancer Epidemiol. Biomarkers Prev. 19(2):537-546(2010). Sun, C., et al. Hum. Mutat. 31(1):99-107(2010). Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009). He, X., et al. Br J Clin Pharmacol 68(5):721-730(2009). Holmes, M.V., et al. PLoS ONE 4 (12), E7960 (2009).

Other Notes

Small volumes of anti-UGT2B15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UGT2B15 purchase

MBS6361189 is an antibody targeting UGT2B15. Also known as UGT2B15, ID (UGT2B15, UGT2B8, UDP-glucuronosyltransferase 2B15, HLUG4, UDP-glucuronosyltransferase 2B8, UDPGTh-3) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UGT2B15. It may not necessarily be applicable to this product.

NCBI GI #
116517299
NCBI GeneID
7366
NCBI Accession #
NP_001067.2
UniProt Primary Accession #
P54855
UniProt Secondary Accession #
P23765; Q9UK63; A6NDX0; A6NNJ4
UniProt Related Accession #
P54855; AAB28536
GenBank Nucleotide #
NM_001076.3
NCBI Official Full Name
UDP-glucuronosyltransferase 2B15
NCBI Official Synonym Full Names
UDP glucuronosyltransferase 2 family, polypeptide B15
NCBI Official Symbol
UGT2B15
NCBI Official Synonym Symbols
HLUG4; UGT2B8; UDPGTH3; UDPGT 2B8; UDPGT2B15
UniProt Protein Name
UDP-glucuronosyltransferase 2B15
UniProt Synonym Protein Names
HLUG4; UDP-glucuronosyltransferase 2B8; UDPGT 2B8; UDPGTh-3
Protein Family
UDP-glucuronosyltransferase
UniProt Gene Name
UGT2B15
UniProt Synonym Gene Names
UGT2B8; UDPGT 2B15; UDPGT 2B8
UniProt Entry Name
UDB15_HUMAN
NCBI Protein Information
UDP-glucuronosyltransferase 2B15; UDPGTh-3; UDPGT 2B15; UDP glycosyltransferase 2B15; UDP-glucuronosyltransferase 2B8; UDP-glucuronosyltransferase UGT2B15; UDP-glucuronyltransferase, family 2, beta-15

NCBI Summary for UGT2B15

This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011]
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UniProt Comments for UGT2B15

UGT2B15: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. Belongs to the UDP-glycosyltransferase family.

Protein type: Transferase; EC 2.4.1.17; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function: retinoic acid binding; glucuronosyltransferase activity

Biological Process: steroid metabolic process; flavonoid biosynthetic process; xenobiotic metabolic process; cellular response to hormone stimulus
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Research Articles on UGT2B15

1. Sipoglitazar clearance is substantially modified by UGT2B15 enzyme variants, with higher exposure observed in the UGT2B15*2/*2 genotype group.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UGT2B15 antibody

 Reference Product  PubMed Publications
 CYP2D6 antibody  >11 publications with UGT2B15 and CYP2D6
 CYP2C9 antibody  >8 publications with UGT2B15 and CYP2C9
 CYP3A5 antibody  >6 publications with UGT2B15 and CYP3A5
 HSD17B2 antibody  >5 publications with UGT2B15 and HSD17B2
 CYP2B6 antibody  >5 publications with UGT2B15 and CYP2B6
 CYP3A4 antibody  >5 publications with UGT2B15 and CYP3A4
 CYP2C19 antibody  >4 publications with UGT2B15 and CYP2C19
 SRD5A2 antibody  >2 publications with UGT2B15 and SRD5A2
 CYP1B1 antibody  >1 publications with UGT2B15 and CYP1B1

Pathways associated with anti-UGT2B15 antibody

 Products by Pathway  Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Glucuronidation Pathway antibodies  Glucuronidation Pathway Diagram

Diseases associated with anti-UGT2B15 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >35 publications with UGT2B15 and Neoplasms
 Prostatic Neoplasms Antibodies  >22 publications with UGT2B15 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >9 publications with UGT2B15 and Breast Neoplasms
 Hyperplasia Antibodies  >3 publications with UGT2B15 and Hyperplasia
 Ovarian Diseases Antibodies  >1 publications with UGT2B15 and Ovarian Diseases
 Disorders of Sex Development Antibodies  >1 publications with UGT2B15 and Disorders of Sex Development
 Lung Neoplasms Antibodies  >1 publications with UGT2B15 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with UGT2B15 and Carcinoma, Hepatocellular
 Cholestasis Antibodies  >1 publications with UGT2B15 and Cholestasis
 Cell Transformation, Neoplastic Antibodies  >1 publications with UGT2B15 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-UGT2B15 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >89 publications with UGT2B15 and Liver
 Intestine Antibodies  >18 publications with UGT2B15 and Intestine
 Testis Antibodies  >4 publications with UGT2B15 and Testis
 Mammary Gland Antibodies  >4 publications with UGT2B15 and Mammary Gland
 Pancreas Antibodies  >1 publications with UGT2B15 and Pancreas
 Bladder Antibodies  >1 publications with UGT2B15 and Bladder
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