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UGT2B7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6002606

The UGTs (EC 2.4.1.17) serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B7 has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
UGT2B7, Polyclonal Antibody
Full Product Name
UGT2B7, NT (UGT2B7, UGTB2B9, UDP-glucuronosyltransferase 2B7, 3,4-catechol estrogen-specific UDPGT, UDP-glucuronosyltransferase 2B9, UDPGTh-2)
Product Gene Name
anti-UGT2B7 antibody
Product Synonym Names
Anti -UGT2B7, NT (UGT2B7, UGTB2B9, UDP-glucuronosyltransferase 2B7, 3,4-catechol estrogen-specific UDPGT, UDP-glucuronosyltransferase 2B9, UDPGTh-2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
60,695 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (69955190..69978705). Location: 4q13
OMIM
600068
3D Structure
ModBase 3D Structure for P16662
Immunogen
UGT2B7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-127 amino acids from the N-terminal region of human UGT2B7.

Product Categories/Family for anti-UGT2B7 antibody

Antibodies; Abs to Enzymes; Glucuronosyltransferase
Applications Tested/Suitable for anti-UGT2B7 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-UGT2B7 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-UGT2B7 antibody

UGT2B7 Antibody (N-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the UGT2B7 antibody detected the UGT2B7 protein (arrow).
Rabbit Anti-UGT2B7 Polyclonal Antibody – Cat# MBS6002606

Other Notes

Small volumes of anti-UGT2B7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UGT2B7 purchase

MBS6002606 is an antibody targeting UGT2B7. Also known as UGT2B7, NT (UGT2B7, UGTB2B9, UDP-glucuronosyltransferase 2B7, 3,4-catechol estrogen-specific UDPGT, UDP-glucuronosyltransferase 2B9, UDPGTh-2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UGT2B7. It may not necessarily be applicable to this product.

NCBI GI #
190194389
NCBI GeneID
7364
NCBI Accession #
NP_001065.2
UniProt Primary Accession #
P16662
UniProt Secondary Accession #
Q6GTW0; B2R810
UniProt Related Accession #
P16662
GenBank Nucleotide #
NM_001074.2
NCBI Official Full Name
UDP-glucuronosyltransferase 2B7
NCBI Official Synonym Full Names
UDP glucuronosyltransferase 2 family, polypeptide B7
NCBI Official Symbol
UGT2B7
NCBI Official Synonym Symbols
UGT2B9; UDPGTH2; UDPGT2B7; UDPGT 2B9
UniProt Protein Name
UDP-glucuronosyltransferase 2B7
UniProt Synonym Protein Names
3,4-catechol estrogen-specific UDPGT; UDP-glucuronosyltransferase 2B9; UDPGT 2B9; UDPGTh-2
Protein Family
UDP-glucuronosyltransferase
UniProt Gene Name
UGT2B7
UniProt Synonym Gene Names
UGTB2B9; UDPGT 2B7; UDPGT 2B9
UniProt Entry Name
UD2B7_HUMAN
NCBI Protein Information
UDP-glucuronosyltransferase 2B7; UDPGTh-2; UDPGT 2B7; 3,4-catechol estrogen specific; UDP glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B9; 3,4-catechol estrogen-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-7

NCBI Summary for UGT2B7

The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011]
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UniProt Comments for UGT2B7

UGT2B7: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family.

Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - androgen and estrogen; EC 2.4.1.17; Membrane protein, integral; Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - ascorbate and aldarate; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 4q13

Cellular Component: endoplasmic reticulum membrane; membrane; intracellular membrane-bound organelle; integral to membrane

Molecular Function: retinoic acid binding; glucuronosyltransferase activity

Biological Process: flavonoid biosynthetic process; androgen metabolic process; lipid metabolic process; cellular response to hormone stimulus
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Research Articles on UGT2B7

1. UGT2B7 SNPs influence lamotrigine pharmacokinetics in Thai patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UGT2B7 antibody

 Reference Product  PubMed Publications
 CYP3A4 antibody  >43 publications with UGT2B7 and CYP3A4
 CYP2D6 antibody  >38 publications with UGT2B7 and CYP2D6
 CYP2C9 antibody  >30 publications with UGT2B7 and CYP2C9
 CYP1A2 antibody  >27 publications with UGT2B7 and CYP1A2
 CYP2B6 antibody  >22 publications with UGT2B7 and CYP2B6
 CYP3A5 antibody  >21 publications with UGT2B7 and CYP3A5
 CYP2C19 antibody  >19 publications with UGT2B7 and CYP2C19
 CYP2A6 antibody  >11 publications with UGT2B7 and CYP2A6
 CYP1B1 antibody  >7 publications with UGT2B7 and CYP1B1
 CYP2C8 antibody  >6 publications with UGT2B7 and CYP2C8

Pathways associated with anti-UGT2B7 antibody

 Products by Pathway  Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
 Ascorbate And Aldarate Metabolism Pathway antibodies  Ascorbate And Aldarate Metabolism Pathway Diagram
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 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram

Diseases associated with anti-UGT2B7 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >22 publications with UGT2B7 and Pain
 Liver Diseases Antibodies  >16 publications with UGT2B7 and Liver Diseases
 Liver Neoplasms Antibodies  >11 publications with UGT2B7 and Liver Neoplasms
 Brain Diseases Antibodies  >10 publications with UGT2B7 and Brain Diseases
 Fatty Liver Antibodies  >10 publications with UGT2B7 and Fatty Liver
 Pain, Postoperative Antibodies  >6 publications with UGT2B7 and Pain, Postoperative
 Drug-Induced Liver Injury Antibodies  >6 publications with UGT2B7 and Drug-Induced Liver Injury
 Adenoma Antibodies  >5 publications with UGT2B7 and Adenoma
 Gastrointestinal Diseases Antibodies  >4 publications with UGT2B7 and Gastrointestinal Diseases
 Vomiting Antibodies  >4 publications with UGT2B7 and Vomiting

Organs/Tissues associated with anti-UGT2B7 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >278 publications with UGT2B7 and Liver
 Kidney Antibodies  >72 publications with UGT2B7 and Kidney
 Intestine Antibodies  >51 publications with UGT2B7 and Intestine
 Brain Antibodies  >10 publications with UGT2B7 and Brain
 Stomach Antibodies  >6 publications with UGT2B7 and Stomach
 Skin Antibodies  >6 publications with UGT2B7 and Skin
 Uterus Antibodies  >5 publications with UGT2B7 and Uterus
 Mammary Gland Antibodies  >3 publications with UGT2B7 and Mammary Gland
 Ovary Antibodies  >2 publications with UGT2B7 and Ovary
 Connective Tissue Antibodies  >2 publications with UGT2B7 and Connective Tissue
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