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UNC13B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8570459

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia… More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
UNC13B, Polyclonal Antibody
Full Product Name
UNC13B Polyclonal Antibody
Product Gene Name
anti-UNC13B antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
180kDa; 182kDa
OMIM
605836
3D Structure
ModBase 3D Structure for O14795
Immunogen
Recombinant protein of human UNC13B (NP_006368.3).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-UNC13B antibody
Western Blot (WB)
Application Notes for anti-UNC13B antibody
WB: 1:500-1:2000

Other Notes

Small volumes of anti-UNC13B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UNC13B purchase

MBS8570459 is an antibody targeting UNC13B. Also known as UNC13B Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UNC13B. It may not necessarily be applicable to this product.

NCBI GI #
2432000
NCBI GeneID
10497
NCBI Accession #
AAC19406.1
UniProt Primary Accession #
O14795
UniProt Related Accession #
O14795
NCBI Official Full Name
Munc13
NCBI Official Synonym Full Names
unc-13 homolog B
NCBI Official Symbol
UNC13B
NCBI Official Synonym Symbols
UNC13; MUNC13; Unc13h2; munc13-2
UniProt Protein Name
Protein unc-13 homolog B
UniProt Synonym Protein Names
Munc13-2
Protein Family
Protein
UniProt Gene Name
UNC13B
UniProt Synonym Gene Names
UNC13; munc13
UniProt Entry Name
UN13B_HUMAN
NCBI Protein Information
protein unc-13 homolog B

UniProt Comments for UNC13B

UNC13B: Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Belongs to the unc-13 family.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: Golgi apparatus; cytoplasm; presynaptic active zone; plasma membrane; terminal button; cell junction; cytosol; neuromuscular junction

Molecular Function: diacylglycerol binding; protein binding; signal transducer activity; metal ion binding; receptor activity

Biological Process: synaptic transmission, glutamatergic; synaptic transmission; glutamate secretion; apoptosis; neurotransmitter secretion; regulation of short-term neuronal synaptic plasticity; excretion; signal transduction; synaptic vesicle priming; neuromuscular junction development; synaptic vesicle docking during exocytosis
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Research Articles on UNC13B

1. Assisted by NSF/alpha-SNAP, syntaxin-1 escapes tomosyn arrest and assembles into the Munc18-1/syntaxin-1 complex. Munc13-1 then catalyzes the transit of syntaxin-1 from the Munc18-1/syntaxin-1 complex to the SNARE complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UNC13B antibody

 Reference Product  PubMed Publications
 RIMS1 antibody  >5 publications with UNC13B and RIMS1
 RAB3A antibody  >3 publications with UNC13B and RAB3A
 RAB34 antibody  >3 publications with UNC13B and RAB34
 SLC17A7 antibody  >1 publications with UNC13B and SLC17A7
 VAMP2 antibody  >1 publications with UNC13B and VAMP2
 STX1A antibody  >1 publications with UNC13B and STX1A

Pathways associated with anti-UNC13B antibody

 Products by Pathway  Pathway Diagram
 Effects Of Botulinum Toxin Pathway antibodies  Effects Of Botulinum Toxin Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-UNC13B antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with UNC13B and Kidney Diseases
 Fibrosis Antibodies  >2 publications with UNC13B and Fibrosis
 Brain Diseases Antibodies  >2 publications with UNC13B and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with UNC13B and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >1 publications with UNC13B and Neurobehavioral Manifestations
 Blood Coagulation Disorders Antibodies  >1 publications with UNC13B and Blood Coagulation Disorders
 Proteinuria Antibodies  >1 publications with UNC13B and Proteinuria
 Congenital Abnormalities Antibodies  >1 publications with UNC13B and Congenital Abnormalities
 Neoplasms Antibodies  >1 publications with UNC13B and Neoplasms

Organs/Tissues associated with anti-UNC13B antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >70 publications with UNC13B and Nerve
 Brain Antibodies  >32 publications with UNC13B and Brain
 Kidney Antibodies  >4 publications with UNC13B and Kidney
 Lung Antibodies  >3 publications with UNC13B and Lung
 Muscle Antibodies  >2 publications with UNC13B and Muscle
 Pancreas Antibodies  >2 publications with UNC13B and Pancreas
 Trachea Antibodies  >1 publications with UNC13B and Trachea
 Eye Antibodies  >1 publications with UNC13B and Eye
 Embryonic Tissue Antibodies  >1 publications with UNC13B and Embryonic Tissue
 Intestine Antibodies  >1 publications with UNC13B and Intestine
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