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UNC5D Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9203437

UNC5D is receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger… More details

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Product Overview

Online Datasheet in PDF
Product Name
UNC5D, Polyclonal Antibody
Full Product Name
UNC5D Antibody (Center)
Product Gene Name
Product Synonym Names
Netrin receptor UNC5D; Protein unc-5 homolog 4; Protein unc-5 homolog D; UNC5D; KIAA1777; UNC5H4
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This UNC5D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-511 amino acids from the Central region of human UNC5D.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
UNC5D peptide (MBS9219635) is used for blocking the activity of UNC5D antibody (MBS9203437)
Molecular Weight
105880
Immunogen Sequence Positions
483-511
3D Structure
ModBase 3D Structure for Q6UXZ4
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-UNC5D antibody

Applications Tested/Suitable for anti-UNC5D antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-UNC5D antibody
WB~~1:1000

Western Blot (WB) of anti-UNC5D antibody

UNC5D Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the UNC5D antibody detected the UNC5D protein (arrow).
Rabbit Anti-UNC5D Polyclonal Antibody – Cat# MBS9203437

Product References and Citations for anti-UNC5D antibody

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wang, H., et al. Biochem. Biophys. Res. Commun. 370(4):594-598(2008)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Zhong, Y., et al. Cereb. Cortex 14(10):1144-1152(2004)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)

Other Notes

Small volumes of anti-UNC5D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UNC5D purchase

MBS9203437 is an antibody targeting UNC5D. Also known as UNC5D Antibody (Center). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UNC5D. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
netrin receptor UNC5D
NCBI Official Synonym Full Names
unc-5 netrin receptor D
NCBI Official Symbol
UNC5D
NCBI Official Synonym Symbols
Unc5h4; PRO34692
UniProt Protein Name
Netrin receptor UNC5D
UniProt Synonym Protein Names
Protein unc-5 homolog 4; Protein unc-5 homolog D
Protein Family
UniProt Gene Name
UNC5D
UniProt Synonym Gene Names
KIAA1777; UNC5H4
UniProt Entry Name
UNC5D_HUMAN
NCBI Protein Information
netrin receptor UNC5D

UniProt Comments for UNC5D

UNC5D: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: cell surface; integral to membrane

Biological Process: axon guidance; pyramidal neuron differentiation; apoptosis; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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