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USP15 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9405426

Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
USP15, Polyclonal Antibody
Full Product Name
USP15 antibody
Product Gene Name
anti-USP15 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Purity/Purification
Purified by antigen-affinity chromatography.
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Molecular Weight
27,094 Da
OMIM
604731
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide contain a sequence corresponding to a region within amino acids 891 and 952 of human USP15
Target Name
USP15

Product Categories/Family for anti-USP15 antibody

Total protein Ab
Applications Tested/Suitable for anti-USP15 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-USP15 antibody
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:250
Immunofluorescence: 1:100-1:200

Testing Data of anti-USP15 antibody

Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE Primary antibody diluted at 1: 1000
Rabbit Anti-USP15 Polyclonal Antibody – Cat# MBS9405426

Immunohistochemistry (IHC) of anti-USP15 antibody

Immunohistochemical analysis of paraffin-embedded N87 xenograft, using USP15 antibody at 1: 100 dilution.
Rabbit Anti-USP15 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9405426

Immunofluorescence (IF) of anti-USP15 antibody

Immunofluorescence analysis of paraformaldehyde-fixed A431, using USP15 antibody at 1: 200 dilution.
Rabbit Anti-USP15 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9405426

Other Notes

Small volumes of anti-USP15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP15 purchase

MBS9405426 is an antibody targeting USP15. Also known as USP15 antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for USP15. It may not necessarily be applicable to this product.

NCBI GI #
14149627
NCBI GeneID
9958
NCBI Accession #
NP_006304
UniProt Secondary Accession #
Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y5B5
UniProt Related Accession #
Q9Y4E8
GenBank Nucleotide #
NM_006313.2
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 15 isoform 2
NCBI Official Synonym Full Names
ubiquitin specific peptidase 15
NCBI Official Symbol
USP15
NCBI Official Synonym Symbols
UNPH4; UNPH-2
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 15
UniProt Synonym Protein Names
Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4
UniProt Gene Name
USP15
UniProt Synonym Gene Names
KIAA0529
UniProt Entry Name
UBP15_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 15

NCBI Summary for USP15

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
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UniProt Comments for USP15

USP15: Protease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 12q14

Cellular Component: cytoplasm; nucleus

Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; SMAD binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; transforming growth factor beta receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway
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Research Articles on USP15

1. These data identify USP15 as an antagonist of Parkin and suggest that USP15 inhibition could be a therapeutic strategy for PD cases caused by reduced Parkin levels.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-USP15 antibody

 Reference Product  PubMed Publications
 SMAD7 antibody  >3 publications with USP15 and SMAD7
 SART3 antibody  >2 publications with USP15 and SART3

Pathways associated with anti-USP15 antibody

 Products by Pathway  Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By TGF-beta Receptor Complex Pathway antibodies  Signaling By TGF-beta Receptor Complex Pathway Diagram
 TGF-beta Receptor Signaling Activates SMADs Pathway antibodies  TGF-beta Receptor Signaling Activates SMADs Pathway Diagram

Diseases associated with anti-USP15 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with USP15 and Breast Neoplasms
 Nervous System Diseases Antibodies  >3 publications with USP15 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with USP15 and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with USP15 and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with USP15 and Heart Diseases
 Necrosis Antibodies  >2 publications with USP15 and Necrosis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with USP15 and Drug-Related Side Effects and Adverse Reactions
 Hyperplasia Antibodies  >1 publications with USP15 and Hyperplasia
 Inflammation Antibodies  >1 publications with USP15 and Inflammation

Organs/Tissues associated with anti-USP15 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with USP15 and Blood
 Bone Antibodies  >5 publications with USP15 and Bone
 Brain Antibodies  >5 publications with USP15 and Brain
 Heart Antibodies  >3 publications with USP15 and Heart
 Vascular Antibodies  >3 publications with USP15 and Vascular
 Embryonic Tissue Antibodies  >2 publications with USP15 and Embryonic Tissue
 Skin Antibodies  >1 publications with USP15 and Skin
 Stomach Antibodies  >1 publications with USP15 and Stomach
 Muscle Antibodies  >1 publications with USP15 and Muscle
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