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USP18 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9608470

Function: Involved in the regulation of inflammatory response to interferon type 1 (PubMed:27325888). Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of… More details

$325 / 0.1 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
USP18, Polyclonal Antibody
Full Product Name
USP18 Antibody
Product Gene Name
Product Synonym Names
43 kDa ISG15 specific protease; 43 kDa ISG15-specific protease; EC 3.1.2.; hUBP43; Interferon Stimulated Gene 43 kD; ISG15 Specific Processing Protease; ISG15-specific-processing protease; ISG43; Ubiquitin Specific Peptidase 18; Ubiquitin Specific Protease 18 43 kD; Ubiquitin Specific Protease 18; Ubl carboxyl terminal hydrolase 18; Ubl carboxyl-terminal hydrolase 18; Ubl thioesterase 18; Ubl thiolesterase 18; Ubp15; UBP18_HUMAN; USP18
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
USP18 antibody detects endogenous levels of total USP18
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
USP18 peptide (MBS9627182) is used for blocking the activity of USP18 antibody (MBS9608470)
Molecular Weight
Observed: 43 kDa
Predicted: 44 kDa
3D Structure
ModBase 3D Structure for Q9UMW8
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human USP18
Subcellular Location
Nucleus
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-USP18 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-USP18 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-USP18 antibody

Western blot analysis of USP18 using Jurkat whole lysates.
Rabbit Anti-USP18 Polyclonal Antibody – Cat# MBS9608470

Other Notes

Small volumes of anti-USP18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for USP18 purchase

MBS9608470 is an antibody targeting USP18. Also known as USP18 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for USP18. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ubl carboxyl-terminal hydrolase 18
NCBI Official Synonym Full Names
ubiquitin specific peptidase 18
NCBI Official Symbol
USP18
NCBI Official Synonym Symbols
ISG43; UBP43; PTORCH2
UniProt Protein Name
Ubl carboxyl-terminal hydrolase 18
UniProt Synonym Protein Names
43 kDa ISG15-specific protease; hUBP43; ISG15-specific-processing protease; Ubl thioesterase 18
UniProt Gene Name
USP18
UniProt Synonym Gene Names
ISG43; hUBP43
NCBI Protein Information
ubl carboxyl-terminal hydrolase 18

NCBI Summary for USP18

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
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UniProt Comments for USP18

Involved in the regulation of inflammatory response to interferon type 1 (PubMed:27325888). Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-USP18 antibody

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