Rabbit Anti-USP21 Polyclonal Antibody – Cat# MBS6505273

USP21 Antibody – Rabbit Polyclonal

Name: USP21 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6505273
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6505273

MBS6505273 is an antibody targeting USP21. Also known as USP21, NT (P31) (Ubiquitin Carboxyl-terminal Hydrolase 21, Ubiquitin Thioesterase 21, Ubiquitin-specific-Processing Protease 21, Deubiquitinating Enzyme 21, PP1490, USP23) (MaxLight 550). Reactive in… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

USP21, Polyclonal Antibody

Full Product Name

USP21, NT (P31) (Ubiquitin Carboxyl-terminal Hydrolase 21, Ubiquitin Thioesterase 21, Ubiquitin-specific-Processing Protease 21, Deubiquitinating Enzyme 21, PP1490, USP23) (MaxLight 550)

Product Gene Name

anti-USP21 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein G Affinity Chromatography.

Specificity

Recognizes human USP21.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

62.656

OMIM

604729

3D Structure

ModBase 3D Structure for Q9UK80

Immunogen

Synthetic peptide selected from the N-terminal region of human USP21 (KLH).

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-USP21 antibody

Antibodies; Proteins

Applications Tested/Suitable for anti-USP21 antibody

Immunohistochemistry (IHC), FLISA, Western Blot (WB)

Application Notes for anti-USP21 antibody

IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Product References and Citations for anti-USP21 antibody

1. Puente, X.S., et al., Nat. Rev. Genet. 4(7):544-558 (2003). 2. Gong, L., et al., J. Biol. Chem. 275(19):14212-14216 (2000). 3. Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996). 4. Smith, T.S., et al., Biochim. Biophys. Acta 1490(1-2), 184-188 (2000).

Other Notes

Small volumes of anti-USP21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for USP21. It may not necessarily be applicable to this product.

NCBI GI #

74027267

NCBI GeneID

27005

NCBI Accession #

NP_036607

UniProt Primary Accession #

Q9UK80

UniProt Related Accession #

Q9UK80

GenBank Nucleotide #

NP_036607.3

NCBI Official Full Name

ubiquitin carboxyl-terminal hydrolase 21 isoform c

NCBI Official Synonym Full Names

ubiquitin specific peptidase 21

NCBI Official Symbol

USP21

NCBI Official Synonym Symbols

USP16; USP23

UniProt Protein Name

Ubiquitin carboxyl-terminal hydrolase 21

UniProt Synonym Protein Names

Deubiquitinating enzyme 21; Ubiquitin thioesterase 21; Ubiquitin-specific-processing protease 21

UniProt Gene Name

USP21

UniProt Synonym Gene Names

USP23

UniProt Entry Name

UBP21_HUMAN

NCBI Protein Information

ubiquitin carboxyl-terminal hydrolase 21

NCBI Summary for USP21

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

UniProt Comments for USP21

USP21: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Belongs to the peptidase C19 family. USP21 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Protease; EC 3.4.19.12; Ubiquitin-specific protease

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; nucleoplasm; plasma membrane

Molecular Function: cysteine-type peptidase activity; metal ion binding; NEDD8-specific protease activity; protein binding; transcription coactivator activity; ubiquitin-specific protease activity

Biological Process: histone deubiquitination; neurite development; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process

Research Articles on USP21

1. USP21 binds and deubiquitinates FOXM1 in breast cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-USP21 antibody

Products by Pathway	Pathway Diagram
Death Receptor Signalling Pathway antibodies	Death Receptor Signalling Pathway Diagram
Integrated Breast Cancer Pathway antibodies	Integrated Breast Cancer Pathway Diagram
Regulation Of TNFR1 Signaling Pathway antibodies	Regulation Of TNFR1 Signaling Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
TNF Signaling Pathway antibodies	TNF Signaling Pathway Diagram
TNFR1-induced NFkappaB Signaling Pathway antibodies	TNFR1-induced NFkappaB Signaling Pathway Diagram
TNFR1-induced Proapoptotic Signaling Pathway antibodies	TNFR1-induced Proapoptotic Signaling Pathway Diagram

Diseases associated with anti-USP21 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>2 publications with USP21 and Necrosis
Neoplasms, Experimental Antibodies	>1 publications with USP21 and Neoplasms, Experimental
Carcinoma, Hepatocellular Antibodies	>1 publications with USP21 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-USP21 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>2 publications with USP21 and Liver
Blood Antibodies	>2 publications with USP21 and Blood
Bone Antibodies	>1 publications with USP21 and Bone
Nerve Antibodies	>1 publications with USP21 and Nerve
Placenta Antibodies	>1 publications with USP21 and Placenta