VAMP7 Antibody – Rabbit Polyclonal

VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28 and Yq12

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; neuron projection; cell surface; intracellular membrane-bound organelle; late endosome membrane; secretory granule membrane; lysosomal membrane; integral to membrane; trans-Golgi network; phagocytic vesicle; pseudopodium; secretory granule; SNARE complex; phagocytic vesicle membrane; membrane; perinuclear region of cytoplasm; apical part of cell; lamellipodium; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: SNAP receptor activity; protein binding; SNARE binding; syntaxin binding

Biological Process: ER to Golgi vesicle-mediated transport; exocytosis; autophagic vacuole fusion; natural killer cell degranulation; neutrophil degranulation; vesicle fusion with Golgi apparatus; endocytosis; calcium ion-dependent exocytosis; vesicle-mediated transport; vesicle fusion; Golgi to plasma membrane protein transport; endosome to lysosome transport; eosinophil degranulation; post-Golgi vesicle-mediated transport; triacylglycerol transport; phagocytosis, engulfment