VPS36 Antibody – Rabbit Polyclonal

VPS36: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. Belongs to the VPS36 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 13q14.3

Cellular Component: membrane; lysosome; late endosome; cytosol; nucleus; endosome

Molecular Function: protein binding; ubiquitin binding; phosphatidylinositol 3-phosphate binding

Biological Process: protein transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; endosome transport