Rabbit Anti-XPC Polyclonal Antibody – Cat# MBS6000168

XPC Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the XPC antibody detected the XPC protein (arrow).

XPC Antibody – Rabbit Polyclonal

Name: XPC Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6000168
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6000168

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A,… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

XPC, Polyclonal Antibody

Full Product Name

XPC, NT (XPC, XPCC, DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125)

Product Gene Name

anti-XPC antibody

Product Synonym Names

Anti -XPC, NT (XPC, XPCC, DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

105,953 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (14186647..14220172, complement). Location: 3p25

OMIM

278720

3D Structure

ModBase 3D Structure for Q01831

Immunogen

XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.

Product Categories/Family for anti-XPC antibody

Antibodies; Abs to DNA Replication; Repair

Applications Tested/Suitable for anti-XPC antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-XPC antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-XPC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XPC purchase

MBS6000168 is an antibody targeting XPC. Also known as XPC, NT (XPC, XPCC, DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for XPC. It may not necessarily be applicable to this product.

NCBI GI #

9438106

NCBI GeneID

7508

NCBI Accession #

AAF87574.1

UniProt Primary Accession #

Q01831

UniProt Secondary Accession #

Q53GT7; Q96AX0; B4DIP3; E9PH69

UniProt Related Accession #

Q01831

NCBI Official Full Name

xeroderma pigmentosum group C protein

NCBI Official Synonym Full Names

xeroderma pigmentosum, complementation group C

NCBI Official Symbol

XPC

NCBI Official Synonym Symbols

XP3; RAD4; XPCC

UniProt Protein Name

DNA repair protein complementing XP-C cells

UniProt Synonym Protein Names

Xeroderma pigmentosum group C-complementing protein; p125

Protein Family

DNA repair protein

UniProt Gene Name

XPC

UniProt Synonym Gene Names

XPCC

UniProt Entry Name

XPC_HUMAN

NCBI Protein Information

DNA repair protein complementing XP-C cells; p125; mutant xeroderma pigmentosum group C

UniProt Comments for XPC

XPC: a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nucleus

Molecular Function: protein binding; damaged DNA binding; bubble DNA binding; single-stranded DNA binding; loop DNA binding

Biological Process: response to drug; nucleotide-excision repair, DNA damage recognition; intra-S DNA damage checkpoint; nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; DNA repair; response to UV-B

Disease: Xeroderma Pigmentosum, Complementation Group C

Research Articles on XPC

1. XPC is required for ATR and ATM recruitment to DNA damage site in UV irradiated cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XPC antibody

Reference Product	PubMed Publications
XPA antibody	>244 publications with XPC and XPA
ERCC2 antibody	>83 publications with XPC and ERCC2
DDB2 antibody	>64 publications with XPC and DDB2
RAD23B antibody	>61 publications with XPC and RAD23B
ERCC5 antibody	>32 publications with XPC and ERCC5
ERCC4 antibody	>27 publications with XPC and ERCC4
CETN2 antibody	>19 publications with XPC and CETN2
DDB1 antibody	>18 publications with XPC and DDB1
ERCC3 antibody	>14 publications with XPC and ERCC3
GTF2H1 antibody	>2 publications with XPC and GTF2H1

Pathways associated with anti-XPC antibody

Products by Pathway	Pathway Diagram
DNA Damage Recognition In GG-NER Pathway antibodies	DNA Damage Recognition In GG-NER Pathway Diagram
DNA Repair Pathway antibodies	DNA Repair Pathway Diagram
Dual Incision Reaction In GG-NER Pathway antibodies	Dual Incision Reaction In GG-NER Pathway Diagram
Formation Of Incision Complex In GG-NER Pathway antibodies	Formation Of Incision Complex In GG-NER Pathway Diagram
Global Genomic NER (GG-NER) Pathway antibodies	Global Genomic NER (GG-NER) Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram
Nucleotide Excision Repair Pathway antibodies	Nucleotide Excision Repair Pathway Diagram

Diseases associated with anti-XPC antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>365 publications with XPC and Neoplasms
Precancerous Conditions Antibodies	>150 publications with XPC and Precancerous Conditions
Carcinoma Antibodies	>95 publications with XPC and Carcinoma
Lung Neoplasms Antibodies	>49 publications with XPC and Lung Neoplasms
Carcinoma, Squamous Cell Antibodies	>36 publications with XPC and Carcinoma, Squamous Cell
Nervous System Diseases Antibodies	>35 publications with XPC and Nervous System Diseases
Adenocarcinoma Antibodies	>29 publications with XPC and Adenocarcinoma
Urinary Bladder Neoplasms Antibodies	>27 publications with XPC and Urinary Bladder Neoplasms
Neoplasms, Experimental Antibodies	>23 publications with XPC and Neoplasms, Experimental
Chromosome Aberrations Antibodies	>21 publications with XPC and Chromosome Aberrations

Organs/Tissues associated with anti-XPC antibody

Organ/Tissue Name	Pubmed Publications
Spleen Antibodies	>6 publications with XPC and Spleen
Thyroid Antibodies	>2 publications with XPC and Thyroid