ZBTB17 Antibody – Rabbit Polyclonal

ZBTB17: May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation. Belongs to the krueppel C2H2-type zinc-finger protein family. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: nucleoplasm

Molecular Function: protein binding; DNA binding; metal ion binding; transcription factor activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; ectoderm development; gastrulation with mouth forming second; negative regulation of cell cycle