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ZC12A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6364775

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis. More details

$1060 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ZC12A, Polyclonal Antibody
Full Product Name
ZC12A, ID (ZC3H12A, MCPIP, MCPIP1, Ribonuclease ZC3H12A, MCP-induced protein 1, Zinc finger CCCH domain-containing protein 12A) (PE)
Product Gene Name
anti-ZC12A antibody
Product Synonym Gene Name
ZC3H12A
Product Synonym Names
ZC3H12A; MCPIP; MCPIP1; Ribonuclease ZC3H12A; MCP-induced protein 1; Zinc finger CCCH domain-containing protein 12A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
610562
3D Structure
ModBase 3D Structure for Q5D1E8
Immunogen
ZC12A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-358 amino acids from the Central region of human ZC12A.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-ZC12A antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-ZC12A antibody
Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-ZC12A antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ZC12A antibody

ZC12A Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ZC12A antibody detected the ZC12A protein (arrow).
Rabbit Anti-ZC12A Polyclonal Antibody – Cat# MBS6364775

Immunohistochemistry (IHC) of anti-ZC12A antibody

ZC12A antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ZC12A antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ZC12A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6364775

Flow Cytometry (FC/FACS) of anti-ZC12A antibody

ZC12A Antibody (Center) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ZC12A Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6364775

Product References and Citations for anti-ZC12A antibody

Skalniak, L., et al. FEBS J. 276(20):5892-5905(2009). Vrotsos, E.G., et al. Brain Res. Bull. 79(2):97-103(2009). Niu, J., et al. J. Biol. Chem. 283(21):14542-14551(2008). Liang, J., et al. J. Biol. Chem. 283(10):6337-6346(2008). Zhou, L., et al. Circ. Res. 98(9):1177-1185(2006).

Other Notes

Small volumes of anti-ZC12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZC12A purchase

MBS6364775 is an antibody targeting ZC12A. Also known as ZC12A, ID (ZC3H12A, MCPIP, MCPIP1, Ribonuclease ZC3H12A, MCP-induced protein 1, Zinc finger CCCH domain-containing protein 12A) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZC12A. It may not necessarily be applicable to this product.

NCBI GI #
156151383
NCBI GeneID
80149
NCBI Accession #
NP_079355.2
UniProt Primary Accession #
Q5D1E8
UniProt Secondary Accession #
Q6I9Z1; Q9H5P1; D3DPT0
UniProt Related Accession #
Q5D1E8
GenBank Nucleotide #
NM_025079.2
NCBI Official Full Name
ribonuclease ZC3H12A
NCBI Official Synonym Full Names
zinc finger CCCH-type containing 12A
NCBI Official Symbol
ZC3H12A
NCBI Official Synonym Symbols
MCPIP; MCPIP1; dJ423B22.1
UniProt Protein Name
Ribonuclease ZC3H12A
UniProt Synonym Protein Names
MCP-induced protein 1; Zinc finger CCCH domain-containing protein 12A
UniProt Gene Name
ZC3H12A
UniProt Entry Name
ZC12A_HUMAN
NCBI Protein Information
ribonuclease ZC3H12A

UniProt Comments for ZC12A

MCPIP1: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Belongs to the ZC3H12 family.

Protein type: Hydrolase; EC 3.1.-.-

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane

Molecular Function: protein binding; endonuclease activity; metal ion binding

Biological Process: apoptosis; inhibition of NF-kappaB transcription factor; negative regulation of nitric oxide biosynthetic process; negative regulation of interleukin-6 production; positive regulation of fat cell differentiation; angiogenesis; negative regulation of tumor necrosis factor production; negative regulation of macrophage activation; cell differentiation; positive regulation of autophagy
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Research Articles on ZC12A

1. In this review we summarize current progress regarding the specific characteristics of sequences and structures in the 3' untranslated regions of mRNAs that are recognized by tristetraproline, Roquins, and Regnase-1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZC12A antibody

 Reference Product  PubMed Publications
 CCL2 antibody  >9 publications with ZC12A and CCL2
 NFKBIZ antibody  >2 publications with ZC12A and NFKBIZ
 IKBKB antibody  >2 publications with ZC12A and IKBKB
 BECN1 antibody  >2 publications with ZC12A and BECN1

Diseases associated with anti-ZC12A antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >24 publications with ZC12A and Inflammation
 Necrosis Antibodies  >13 publications with ZC12A and Necrosis
 Disease Models, Animal Antibodies  >7 publications with ZC12A and Disease Models, Animal
 Death Antibodies  >7 publications with ZC12A and Death
 Liver Diseases Antibodies  >5 publications with ZC12A and Liver Diseases
 Nervous System Diseases Antibodies  >5 publications with ZC12A and Nervous System Diseases
 Lung Diseases Antibodies  >4 publications with ZC12A and Lung Diseases
 Anemia Antibodies  >3 publications with ZC12A and Anemia
 Heart Diseases Antibodies  >2 publications with ZC12A and Heart Diseases
 Arterial Occlusive Diseases Antibodies  >2 publications with ZC12A and Arterial Occlusive Diseases

Organs/Tissues associated with anti-ZC12A antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with ZC12A and Liver
 Lung Antibodies  >6 publications with ZC12A and Lung
 Spleen Antibodies  >5 publications with ZC12A and Spleen
 Vascular Antibodies  >5 publications with ZC12A and Vascular
 Brain Antibodies  >3 publications with ZC12A and Brain
 Muscle Antibodies  >3 publications with ZC12A and Muscle
 Heart Antibodies  >3 publications with ZC12A and Heart
 Thymus Antibodies  >2 publications with ZC12A and Thymus
 Lymph Node Antibodies  >2 publications with ZC12A and Lymph Node
 Placenta Antibodies  >1 publications with ZC12A and Placenta
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