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ZC3HAV1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151558

ZC3HAV1 Antibody: The zinc finger antiviral protein (ZC3HAV1) is a CCCH type zinc finger protein that induces an innate immunity to infections by retrovirus by preventing the accumulation of viral RNAs in the cytoplasm and recruits the RNA processing exosome… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
ZC3HAV1, Polyclonal Antibody
Full Product Name
ZC3HAV1 Antibody
Product Gene Name
anti-ZC3HAV1 antibody
Product Synonym Names
ZC3HAV1; ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2; PRO1677; Zinc finger CCCH-type antiviral protein 1; ADP-ribosyltransferase diphtheria toxin-like 13; zinc finger CCCH-type, antiviral 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
ZC3HAV1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
ZC3HAV1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ZC3HAV1 peptide (MBS152092) is used for blocking the activity of ZC3HAV1 antibody (MBS151558)
Molecular Weight
18,586 Da
OMIM
607312
3D Structure
ModBase 3D Structure for Q7Z2W4
Conjugate
Unconjugated
Immunogen
ZC3HAV1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human ZC3HAV1.
Buffer
ZC3HAV1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ZC3HAV1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-ZC3HAV1 antibody
ZC3HAV1 antibody can be used for detection of ZC3HAV1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ZC3HAV1 antibody

Western blot analysis of ZC3HAV1 in HeLa cell lysate with ZC3HAV1 antibody at 1μg/mL in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-ZC3HAV1 Polyclonal Antibody – Cat# MBS151558

Immunocytochemistry (IHC) of anti-ZC3HAV1 antibody

Immunocytochemistry of ZC3HAV1 in HeLa cells with ZC3HAV1 antibody at 20 μg/mL.
Rabbit Anti-ZC3HAV1 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS151558

Immunofluorescence (IF) of anti-ZC3HAV1 antibody

Immunofluorescence of ZC3HAV1 in Hela cells with ZC3HAV1 antibody at 20 μg/mL.
Rabbit Anti-ZC3HAV1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151558

Other Notes

Small volumes of anti-ZC3HAV1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZC3HAV1 purchase

MBS151558 is an antibody targeting ZC3HAV1. Also known as ZC3HAV1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZC3HAV1. It may not necessarily be applicable to this product.

NCBI GI #
27477138
NCBI GeneID
56829
NCBI Accession #
NP_078901
UniProt Primary Accession #
Q7Z2W4
UniProt Secondary Accession #
Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7; A4D1R2; A4D1S4
UniProt Related Accession #
Q7Z2W4
GenBank Nucleotide #
NM_024625.3
NCBI Official Full Name
zinc finger CCCH-type antiviral protein 1 isoform 2
NCBI Official Synonym Full Names
zinc finger CCCH-type, antiviral 1
NCBI Official Symbol
ZC3HAV1
NCBI Official Synonym Symbols
ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2
UniProt Protein Name
Zinc finger CCCH-type antiviral protein 1
UniProt Synonym Protein Names
ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Zinc finger CCCH domain-containing protein 2; Zinc finger antiviral protein; ZAP
Protein Family
Zinc finger CCCH-type antiviral protein
UniProt Gene Name
ZC3HAV1
UniProt Synonym Gene Names
ZC3HDC2; ARTD13; ZAP
UniProt Entry Name
ZCCHV_HUMAN
NCBI Protein Information
zinc finger CCCH-type antiviral protein 1; zinc finger CCCH domain-containing protein 2; ADP-ribosyltransferase diphtheria toxin-like 13

NCBI Summary for ZC3HAV1

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]
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UniProt Comments for ZC3HAV1

ZAP: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; RNA-binding

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: Golgi apparatus; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; NAD+ ADP-ribosyltransferase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of viral genome replication; metabolic process; response to virus; positive regulation of interferon-beta production; innate immune response; defense response to virus; positive regulation of interferon-alpha production
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Research Articles on ZC3HAV1

1. Contrary to previous assumptions, these results indicate an essential function of the PARP-like domain in hZAP-L's antiviral activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZC3HAV1 antibody

 Reference Product  PubMed Publications
 DDX58 antibody  >2 publications with ZC3HAV1 and DDX58
 OASL antibody  >1 publications with ZC3HAV1 and OASL

Diseases associated with anti-ZC3HAV1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with ZC3HAV1 and Nervous System Diseases
 Hepatitis Antibodies  >1 publications with ZC3HAV1 and Hepatitis
 Inflammation Antibodies  >1 publications with ZC3HAV1 and Inflammation
 Liver Diseases Antibodies  >1 publications with ZC3HAV1 and Liver Diseases

Organs/Tissues associated with anti-ZC3HAV1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with ZC3HAV1 and Lung
 Brain Antibodies  >1 publications with ZC3HAV1 and Brain
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