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ZEB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6365097

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are… More details

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Product Overview

Online Datasheet in PDF
Product Name
ZEB2, Polyclonal Antibody
Full Product Name
ZEB2, CT (ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B, Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1, Zinc finger homeobox protein 1b) (Biotin)
Product Gene Name
anti-ZEB2 antibody
Product Synonym Names
ZEB2; KIAA0569; SIP1; ZFHX1B; ZFX1B; Zinc finger E-box-binding homeobox 2; Smad-interacting protein 1; Zinc finger homeobox protein 1b
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human ZEB2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
133,806 Da
OMIM
235730
3D Structure
ModBase 3D Structure for O60315
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 1078-1105 in the C-terminal region of human ZEB2. Species sequence homology: mouse
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-ZEB2 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox
Applications Tested/Suitable for anti-ZEB2 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
Application Notes for anti-ZEB2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ZEB2 antibody

Western Blot analysis in MDA-MB435 cell line lysates (35ug/lane) usingMBS6006181. This demonstrates that MBS6006181 detected the ZEB2 protein (arrow).
Rabbit Anti-ZEB2 Polyclonal Antibody – Cat# MBS6365097

Western Blot (WB) of anti-ZEB2 antibody

Western Blot analysis in Hela cell nucleus lysate (20ug) usingMBS6006181. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 136kD. Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-ZEB2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6365097

Product References and Citations for anti-ZEB2 antibody

1. Kumar, P.A., et al. J. Biol. Chem. 285(41):31148-31156(2010). 2. Li, A., et al. Cancer Res. 70(13):5226-5237(2010). 3. Ohashi, S., et al. Cancer Res. 70(10):4174-4184(2010). 4. Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010). 5. Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010).

Other Notes

Small volumes of anti-ZEB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZEB2 purchase

MBS6365097 is an antibody targeting ZEB2. Also known as ZEB2, CT (ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B, Zinc finger E-box-binding homeobox 2, Smad-interacting protein 1, Zinc finger homeobox protein 1b) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZEB2. It may not necessarily be applicable to this product.

NCBI GI #
7662184
NCBI GeneID
9839
NCBI Accession #
NP_055610.1
NCBI Related Accession #
NP_001165124.1
UniProt Primary Accession #
O60315
UniProt Secondary Accession #
Q9UED1; A0JP09; B7Z2P2; F5H814
UniProt Related Accession #
O60315
GenBank Nucleotide #
NM_014795.3
NCBI Official Full Name
zinc finger E-box-binding homeobox 2 isoform 1
NCBI Official Synonym Full Names
zinc finger E-box binding homeobox 2
NCBI Official Symbol
ZEB2
NCBI Official Synonym Symbols
SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1
UniProt Protein Name
Zinc finger E-box-binding homeobox 2
UniProt Synonym Protein Names
Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b
Protein Family
Zinc finger E-box-binding homeobox
UniProt Gene Name
ZEB2
UniProt Synonym Gene Names
KIAA0569; SIP1; ZFHX1B; ZFX1B; SMADIP1
UniProt Entry Name
ZEB2_HUMAN
NCBI Protein Information
zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; SMAD interacting protein 1; Smad-interacting protein 1

UniProt Comments for ZEB2

ZEB2: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS); also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 2q22.3

Cellular Component: nucleus

Molecular Function: DNA binding; phosphatase regulator activity; metal ion binding

Biological Process: positive regulation of JNK activity; nervous system development; somitogenesis; transcription, DNA-dependent; cell proliferation in forebrain; pigmentation during development; hippocampus development; positive regulation of melanin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of melanocyte differentiation; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; neural crest cell migration; positive regulation of Wnt receptor signaling pathway

Disease: Mowat-wilson Syndrome
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Research Articles on ZEB2

1. ZEB2 is a possible candidate gene for primary asplenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZEB2 antibody

 Reference Product  PubMed Publications
 CDH1 antibody  >23 publications with ZEB2 and CDH1
 SMAD2 antibody  >6 publications with ZEB2 and SMAD2
 SMAD3 antibody  >5 publications with ZEB2 and SMAD3
 MEOX2 antibody  >3 publications with ZEB2 and MEOX2
 CBX4 antibody  >1 publications with ZEB2 and CBX4
 CTBP2 antibody  >1 publications with ZEB2 and CTBP2
 SMAD5 antibody  >1 publications with ZEB2 and SMAD5

Pathways associated with anti-ZEB2 antibody

 Products by Pathway  Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-ZEB2 antibody

 Disease Name  Pubmed Publications
 Mowat-Wilson syndrome Antibodies  >62 publications with ZEB2 and Mowat-Wilson syndrome
 Neoplasm Metastasis Antibodies  >58 publications with ZEB2 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >56 publications with ZEB2 and Neoplasm Invasiveness
 Disease Progression Antibodies  >42 publications with ZEB2 and Disease Progression
 Breast Neoplasms Antibodies  >39 publications with ZEB2 and Breast Neoplasms
 Heart Defects, Congenital Antibodies  >22 publications with ZEB2 and Heart Defects, Congenital
 Cell Transformation, Neoplastic Antibodies  >22 publications with ZEB2 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >19 publications with ZEB2 and Lung Diseases
 Kidney Diseases Antibodies  >19 publications with ZEB2 and Kidney Diseases
 Liver Neoplasms Antibodies  >19 publications with ZEB2 and Liver Neoplasms

Organs/Tissues associated with anti-ZEB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >37 publications with ZEB2 and Lung
 Kidney Antibodies  >35 publications with ZEB2 and Kidney
 Embryonic Tissue Antibodies  >33 publications with ZEB2 and Embryonic Tissue
 Heart Antibodies  >32 publications with ZEB2 and Heart
 Liver Antibodies  >30 publications with ZEB2 and Liver
 Brain Antibodies  >26 publications with ZEB2 and Brain
 Blood Antibodies  >21 publications with ZEB2 and Blood
 Nerve Antibodies  >21 publications with ZEB2 and Nerve
 Eye Antibodies  >18 publications with ZEB2 and Eye
 Muscle Antibodies  >17 publications with ZEB2 and Muscle
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