ZFP36 Antibody – Rabbit Polyclonal

TTP: a CCCH zinc finger protein that has anti-inflammatory and arthritis suppressor activity. Regulates inflammatory responses at the post-transcriptional level. TTP deficiency in mice causes a severe inflammatory syndrome that includes autoimmunity, myeloid hyperplasia, and erosive arthritis. Binds to and destabilizes mRNA molecules with AU-rich elements (AREs). Has a high affinity for UUAUUUAUU mRNA sequences. Destabilizes tumor necrosis factor-alpha (TNF??), interleukin 2 (IL2), granulocyte-macrophage colony-stimulating factor (GM-CSF), transcription factor E47, and cyclooxygenase 2 (COX2) mRNAs. TNF?? and GM-CSF mRNAs are stabilized in TTP-deficient mice, causing a severe inflammatory syndrome. Conversely, high levels of TTP reduce inflammatory responses. TTP is a very low abundance protein that is rapidly induced by insulin, glucocorticoids, lipopolysaccharide (LPS), fetal calf serum, zinc, herpes simplex virus 1, green tea, and cinnamon. Once induced, the TTP protein is relatively stable. Has been experimentaly shown to be able to bind zinc. TTP is extensively phosphorylated.

Protein type: DNA-binding; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: CCR4-NOT complex; cytoplasm; cytosol; exosome (RNase complex); nucleus; ribonucleoprotein complex; stress granule

Molecular Function: AU-rich element binding; C-C chemokine binding; enzyme binding; heat shock protein binding; mRNA 3'-UTR binding; mRNA binding; protein binding; protein kinase binding; single-stranded RNA binding

Biological Process: MAPKKK cascade; miRNA-mediated gene silencing, negative regulation of translation; mRNA catabolic process; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, deadenylation-independent decay; mRNA transport; negative regulation of erythrocyte differentiation; negative regulation of interleukin-2 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral transcription; poly(A) tail shortening; positive regulation of fat cell differentiation; regulation of keratinocyte differentiation; regulation of mRNA stability; regulation of tumor necrosis factor production; response to starvation; response to wounding