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SGK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1752946

Description: Rabbit IgG polyclonal antibody for SGK1 detection. Tested with WB, IHC-P in Human;Monkey.Background: Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SGK1, Polyclonal Antibody
Full Product Name
Anti-SGK1 Antibody
Product Gene Name
anti-SGK1 antibody
Product Synonym Names
Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1; SGK1; SGK
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Monkey
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purity/Purification
Immunogen affinity purified.
Specificity
No cross reactivity with other proteins.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
OMIM
602958
3D Structure
ModBase 3D Structure for O00141
Immunogen
A synthetic peptide corresponding to a sequence of human SGK1(AILIAFMKQRRMGLNDFIQKIAN).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-SGK1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Application Notes for anti-SGK1 antibody
WB: 0.25-0.5ug/ml (Human, Monkey)
IHC-P (Embedded Section): 0.5-1ug/ml (Human)
Tested Species: In-house tested species with positive results.

Product References and Citations for anti-SGK1 antibody

1. Arteaga, M. F., Coric, T., Straub, C., Canessa, C. M. A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons. Proc. Nat. Acad. Sci. 105: 4459-4464, 2008.
2. Arteaga, M. F., Wang, L., Ravid, T., Hochstrasser, M., Canessa, C. M. An amphipathic helix targets serum and glucocorticoid-induced kinase 1 to the endoplasmic reticulum-associated ubiquitin-conjugation machinery. Proc. Nat. Acad. Sci. 103: 11178-11183, 2006.
3. Gamper, N., Fillon, S., Feng, Y., Friedrich, B., Lang, P. A., Henke, G., Huber, S. M., Kobayashi, T., Cohen, P., Lang, F. K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK. Pflugers Arch. 445: 60-66, 2002.

Other Notes

Small volumes of anti-SGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SGK1 purchase

MBS1752946 is an antibody targeting SGK1. Reactive in Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SGK1. It may not necessarily be applicable to this product.

NCBI GI #
219521876
NCBI GeneID
6446
NCBI Accession #
NP_001137148.1
UniProt Primary Accession #
O00141
UniProt Related Accession #
O00141
GenBank Nucleotide #
NP_001137148.1
NCBI Official Full Name
serine/threonine-protein kinase Sgk1 isoform 2
NCBI Official Synonym Full Names
serum/glucocorticoid regulated kinase 1
NCBI Official Symbol
SGK1
NCBI Official Synonym Symbols
SGK
UniProt Protein Name
Serine/threonine-protein kinase Sgk1
UniProt Synonym Protein Names
Serum/glucocorticoid-regulated kinase 1
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
SGK1
UniProt Synonym Gene Names
SGK
UniProt Entry Name
SGK1_HUMAN
NCBI Protein Information
serine/threonine-protein kinase Sgk1

NCBI Summary for SGK1

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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UniProt Comments for SGK1

SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; Protein kinase, AGC; EC 2.7.11.1; AGC group; SGK family

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; mitochondrion; cytoplasm; plasma membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; potassium channel regulator activity; chloride channel regulator activity; sodium channel regulator activity; calcium channel regulator activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: apoptosis; sodium ion transport; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of cell migration; regulation of cell proliferation; regulation of apoptosis; regulation of transcription factor activity; long-term memory; regulation of catalytic activity; regulation of blood pressure; response to stress; regulation of cell growth; transmembrane transport; response to DNA damage stimulus
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Research Articles on SGK1

1. SGK1 expression is upregulated by IL-18 in vascular smooth muscle cells (VSMCs), and SGK1 participates in the intracellular signaling of IL-18-induced osteo-/chondrogenic transdifferentiation of VSMCs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SGK1 antibody

 Reference Product  PubMed Publications
 NEDD4 antibody  >78 publications with SGK1 and NEDD4
 CTNNB1 antibody  >17 publications with SGK1 and CTNNB1
 KCNJ1 antibody  >11 publications with SGK1 and KCNJ1
 FOXO3 antibody  >7 publications with SGK1 and FOXO3
 NEDD4L antibody  >3 publications with SGK1 and NEDD4L
 PDK2 antibody  >2 publications with SGK1 and PDK2
 SLC9A3R2 antibody  >2 publications with SGK1 and SLC9A3R2
 NEK6 antibody  >1 publications with SGK1 and NEK6
 GSK3A antibody  >1 publications with SGK1 and GSK3A
 CREB1 antibody  >1 publications with SGK1 and CREB1

Pathways associated with anti-SGK1 antibody

 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram

Diseases associated with anti-SGK1 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >65 publications with SGK1 and Hypertension
 Kidney Diseases Antibodies  >40 publications with SGK1 and Kidney Diseases
 Cardiovascular Diseases Antibodies  >40 publications with SGK1 and Cardiovascular Diseases
 Fibrosis Antibodies  >37 publications with SGK1 and Fibrosis
 Neoplasms Antibodies  >37 publications with SGK1 and Neoplasms
 Inflammation Antibodies  >22 publications with SGK1 and Inflammation
 Nervous System Diseases Antibodies  >19 publications with SGK1 and Nervous System Diseases
 Proteinuria Antibodies  >17 publications with SGK1 and Proteinuria
 Carcinoma Antibodies  >11 publications with SGK1 and Carcinoma
 Heart Diseases Antibodies  >10 publications with SGK1 and Heart Diseases

Organs/Tissues associated with anti-SGK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >184 publications with SGK1 and Kidney
 Blood Antibodies  >129 publications with SGK1 and Blood
 Brain Antibodies  >35 publications with SGK1 and Brain
 Heart Antibodies  >31 publications with SGK1 and Heart
 Lung Antibodies  >31 publications with SGK1 and Lung
 Muscle Antibodies  >29 publications with SGK1 and Muscle
 Intestine Antibodies  >20 publications with SGK1 and Intestine
 Liver Antibodies  >18 publications with SGK1 and Liver
 Bone Antibodies  >12 publications with SGK1 and Bone
 Vascular Antibodies  >12 publications with SGK1 and Vascular
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