• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

XRCC6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8573339

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of… More details

$380 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
XRCC6, Polyclonal Antibody
Full Product Name
XRCC6 Polyclonal Antibody
Product Gene Name
anti-XRCC6 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Monkey
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
65kDa; 69kDa
OMIM
152690
3D Structure
ModBase 3D Structure for P12956
Immunogen
Recombinant protein of human XRCC6 (NP_001460.1).
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-XRCC6 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
Application Notes for anti-XRCC6 antibody
WB: 1:500-1:2000
IHC: 1:50-1:100
IF: 1:50-1:100
IP: 1:20-1:50

Other Notes

Small volumes of anti-XRCC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XRCC6 purchase

MBS8573339 is an antibody targeting XRCC6. Also known as XRCC6 Polyclonal Antibody. Reactive in Human, Mouse, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for XRCC6. It may not necessarily be applicable to this product.

NCBI GI #
4503841
NCBI GeneID
2547
NCBI Accession #
NP_001460.1
UniProt Primary Accession #
P12956
UniProt Related Accession #
P12956
GenBank Nucleotide #
NP_001460.1
NCBI Official Full Name
X-ray repair cross-complementing protein 6 isoform 1
NCBI Official Synonym Full Names
X-ray repair cross complementing 6
NCBI Official Symbol
XRCC6
NCBI Official Synonym Symbols
ML8; KU70; TLAA; CTC75; CTCBF; G22P1
UniProt Protein Name
X-ray repair cross-complementing protein 6
UniProt Synonym Protein Names
5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
Protein Family
X-ray repair cross-complementing protein
UniProt Gene Name
XRCC6
UniProt Synonym Gene Names
G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA
UniProt Entry Name
XRCC6_HUMAN
NCBI Protein Information
X-ray repair cross-complementing protein 6

UniProt Comments for XRCC6

Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: Helicase; EC 3.6.4.-; DNA-binding; DNA repair, damage; Nuclear receptor co-regulator; EC 4.2.99.-; RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; transcription factor complex; nuclear telomere cap complex; membrane; nucleolus; cytosol; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; double-stranded DNA binding; damaged DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding

Biological Process: positive regulation of neurogenesis; V(D)J recombination; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; DNA repair; double-strand break repair via nonhomologous end joining; DNA duplex unwinding; DNA ligation; double-strand break repair; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; telomere maintenance
Show more

Research Articles on XRCC6

1. dynamic equilibrium of acetylation/deacetylation of Ku70 lysine residues K317, K331 and K338 is critical for optimal repair of radiation-induced DNA-double strand breaks

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XRCC6 antibody

 Reference Product  PubMed Publications
 XRCC5 antibody  >14 publications with XRCC6 and XRCC5
 PRKDC antibody  >4 publications with XRCC6 and PRKDC
 PCNA antibody  >2 publications with XRCC6 and PCNA
 MRE11A antibody  >2 publications with XRCC6 and MRE11A
 PARP1 antibody  >1 publications with XRCC6 and PARP1
 CHEK1 antibody  >1 publications with XRCC6 and CHEK1
 CDKN1A antibody  >1 publications with XRCC6 and CDKN1A
 APEX1 antibody  >1 publications with XRCC6 and APEX1
 WRN antibody  >1 publications with XRCC6 and WRN
 TP53 antibody  >1 publications with XRCC6 and TP53

Pathways associated with anti-XRCC6 antibody

 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram

Diseases associated with anti-XRCC6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with XRCC6 and Neoplasms
 Carcinoma Antibodies  >10 publications with XRCC6 and Carcinoma
 Adenocarcinoma Antibodies  >8 publications with XRCC6 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >4 publications with XRCC6 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >4 publications with XRCC6 and Breast Neoplasms
 Lung Neoplasms Antibodies  >3 publications with XRCC6 and Lung Neoplasms
 Liver Diseases Antibodies  >3 publications with XRCC6 and Liver Diseases
 Lymphoma Antibodies  >3 publications with XRCC6 and Lymphoma
 Liver Neoplasms Antibodies  >3 publications with XRCC6 and Liver Neoplasms
 Leukemia Antibodies  >2 publications with XRCC6 and Leukemia

Organs/Tissues associated with anti-XRCC6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with XRCC6 and Blood
 Liver Antibodies  >4 publications with XRCC6 and Liver
 Lung Antibodies  >3 publications with XRCC6 and Lung
 Kidney Antibodies  >2 publications with XRCC6 and Kidney
 Testis Antibodies  >2 publications with XRCC6 and Testis
 Brain Antibodies  >2 publications with XRCC6 and Brain
 Prostate Antibodies  >1 publications with XRCC6 and Prostate
 Connective Tissue Antibodies  >1 publications with XRCC6 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with XRCC6 and Embryonic Tissue
 Skin Antibodies  >1 publications with XRCC6 and Skin
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000