SNX2 Antibody – Rabbit Polyclonal

This gene belongs to the sorting nexin family whose members contain the phosphoinositide-binding phox (PX) domain. The encoded protein is a component of the retromer complex which plays a role in protein sorting in the endocytic pathway. This protein may form oligomeric complexes with other family members. Alternate splicing results in multiple transcript variants of this gene. Pseudogenes associated with this gene are located on chromosomes 1 and 7. [provided by RefSeq, May 2013]

SNX2: May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Belongs to the sorting nexin family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 5q23

Cellular Component: protein complex; extrinsic to membrane; intracellular membrane-bound organelle; membrane; retromer complex; early endosome membrane; lamellipodium; cytoplasm; endosome membrane

Molecular Function: protein binding; insulin receptor binding; phosphoinositide binding; epidermal growth factor receptor binding

Biological Process: intracellular protein transport; vesicle organization and biogenesis; endocytosis; retrograde transport, endosome to Golgi; protein oligomerization