Rabbit Anti-SOCS1 Polyclonal Antibody – Cat# MBS544935

SOCS1 Antibody – Rabbit Polyclonal

Name: SOCS1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS544935
Price: 610 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS544935

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase… More details

$610 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SOCS1, Polyclonal Antibody

Full Product Name

SOCS1 Antibody BIOTIN-Conjugated

Product Gene Name

anti-SOCS1 antibody

Product Synonym Names

CISH 1; Cytokine Inducible SH2 Protein 1; JAB; JAK-binding protein; Janus kinase binding protein; SOCS-1; SSI1; STAT Induced STAT Inhibitor 1; Suppressor of cytokine signaling 1; TEC Interacting Protein 3; TIP3 antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Monkey, Mouse, Rat

Form/Format

BIOTIN-Conjugated

Concentration

0.64-0.72 ug/ul in antibody stabilization buffer (lot specific)

Preparation and Storage

-20 degree C for long term storage

Matching Pairs

Antibody: SOCS1 (MBS544935)
Positive Control: SOCS1 (MBS543273)

Antibody/Peptide Pairs

SOCS1 peptide (MBS544497) is used for blocking the activity of SOCS1 antibody (MBS544935)

Molecular Weight

11,267 Da

3D Structure

ModBase 3D Structure for P13848

Immunogen

Synthetic peptide taken within amino acid region 170-212 on human Suppressor of Cytokine signaling 1 protein.

Expression

Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.

Molecular Function

Insulin-like growth factor receptor binding; Protein kinase binding; Kinase inhibitor activity

Structure

Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV. Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC (SOCS1) E3 ubiquitin-protein ligase complex which contains Elongin BC, CUL5, RBX1 and SOCS1. Interacts (via SH2 domain and SOCS box) with TRIM8. Interacts with AXL, CUL2 and FGFR3. Interacts with INSR.

Subcellular Location

Nucleus; Cytoplasmic vesicle

Applications Tested/Suitable for anti-SOCS1 antibody

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Application Notes for anti-SOCS1 antibody

Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500

Other Notes

Small volumes of anti-SOCS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SOCS1 purchase

MBS544935 is an antibody targeting SOCS1. Also known as SOCS1 Antibody BIOTIN-Conjugated. Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SOCS1. It may not necessarily be applicable to this product.

NCBI GI #

15524

NCBI Accession #

CAA27974.1

UniProt Primary Accession #

P13848

UniProt Secondary Accession #

Q70AA8; B3VMP2

NCBI Official Full Name

unnamed protein product

UniProt Protein Name

Capsid assembly scaffolding protein

UniProt Synonym Protein Names

Gene product 7Curated; gp7Curated; Head morphogenesis proteinCurated; Protein p7Curated; Scaffold proteinCurated

Protein Family

Suppressor of cytokine signaling

UniProt Gene Name

UniProt Synonym Gene Names

gp7Curated

UniProt Entry Name

SCAF_BPPH2

UniProt Comments for SOCS1

Scaffolding protein involved in the icosahedric procapsid assembly. Coassembles with the capsid proteins to form the procapsid. The scaffolding protein is found within the capsid as a serie of concentric shells. During DNA packaging, the scaffolding protein molecules are released from the procapsid.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.