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ALDH1L1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6462249

MBS6462249 is an antibody targeting ALDH1L1. Also known as ALDH1L1, CT (Aldehyde Dehydrogenase Family 1 Member L1, 10-formyltetrahydrofolate Dehydrogenase, 10-FTHFDH, FTHFD) (APC). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ALDH1L1, Polyclonal Antibody
Full Product Name
ALDH1L1, CT (Aldehyde Dehydrogenase Family 1 Member L1, 10-formyltetrahydrofolate Dehydrogenase, 10-FTHFDH, FTHFD) (APC)
Product Gene Name
anti-ALDH1L1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human ALDH1L1. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
55,394 Da
OMIM
600249
3D Structure
ModBase 3D Structure for O75891
Immunogen
Synthetic peptide corresponding to a region between corresponding to a portion of amino acids within aa724-754 from the C-terminal region of human ALDH1L1, conjugated to KLH.
Conjugate
APC
Note
Preservative Free

Product Categories/Family for anti-ALDH1L1 antibody

Antibodies; Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-ALDH1L1 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-ALDH1L1 antibody
IHC: 1:50-1:100
ELISA: 1:1000
WB: 1:50-1:100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ALDH1L1 antibody

Western blot analysis of anti-ALDH1L1 Antibody (C-term) in mouse liver tissue lysates (35ug/lane). ALDH1L1(arrow) was detected using the purified Pab.
Rabbit Anti-ALDH1L1 Polyclonal Antibody – Cat# MBS6462249

Immunohistochemistry (IHC) of anti-ALDH1L1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ALDH1L1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-ALDH1L1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6462249

Product References and Citations for anti-ALDH1L1 antibody

1. Hosgood, H.D. III, Carcinogenesis 29(10), 1938-1943 (2008). 2. Lee, K.M., Hum. Genet. 122(5), 525-533 (2007).

Other Notes

Small volumes of anti-ALDH1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH1L1. It may not necessarily be applicable to this product.

NCBI GI #
21614513
NCBI GeneID
10840
NCBI Accession #
NP_036322
UniProt Primary Accession #
O75891
UniProt Secondary Accession #
Q68CS1; Q8TBP8; B4DG36; E9PBX3
UniProt Related Accession #
O75891
GenBank Nucleotide #
NM_012190.3
NCBI Official Full Name
cytosolic 10-formyltetrahydrofolate dehydrogenase isoform 2
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family, member L1
NCBI Official Symbol
ALDH1L1
NCBI Official Synonym Symbols
FDH; FTHFD; 10-fTHF; 10-FTHFDH
UniProt Protein Name
Cytosolic 10-formyltetrahydrofolate dehydrogenase
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 1 member L1
Protein Family
Cytosolic 10-formyltetrahydrofolate dehydrogenase
UniProt Gene Name
ALDH1L1
UniProt Synonym Gene Names
FTHFD; 10-FTHFDH; FDH
UniProt Entry Name
AL1L1_HUMAN
NCBI Protein Information
cytosolic 10-formyltetrahydrofolate dehydrogenase

NCBI Summary for ALDH1L1

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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UniProt Comments for ALDH1L1

ALDH1L1: 2 isoforms of the human protein are produced by alternative splicing

Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; Oxidoreductase; EC 1.5.1.6

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: mitochondrion

Molecular Function: methyltransferase activity; aldehyde dehydrogenase (NAD) activity; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity

Biological Process: methylation; biosynthetic process; one-carbon compound metabolic process; 10-formyltetrahydrofolate catabolic process
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Research Articles on ALDH1L1

1. JNK1/2 phosphorylate Bid at Thr59 within the caspase cleavage site in response to ALDH1L1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALDH1L1 antibody

 Reference Product  PubMed Publications
 MTR antibody  >1 publications with ALDH1L1 and MTR
 SHMT1 antibody  >1 publications with ALDH1L1 and SHMT1
 MTHFD1 antibody  >1 publications with ALDH1L1 and MTHFD1

Pathways associated with anti-ALDH1L1 antibody

 Products by Pathway  Pathway Diagram
 Folate-Alcohol And Cancer Pathway antibodies  Folate-Alcohol And Cancer Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 Folate Transformations I Pathway antibodies  Folate Transformations I Pathway Diagram

Diseases associated with anti-ALDH1L1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with ALDH1L1 and Disease Models, Animal
 Brain Diseases Antibodies  >4 publications with ALDH1L1 and Brain Diseases
 Liver Diseases Antibodies  >3 publications with ALDH1L1 and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with ALDH1L1 and Liver Neoplasms
 Death Antibodies  >3 publications with ALDH1L1 and Death
 Carcinoma, Hepatocellular Antibodies  >2 publications with ALDH1L1 and Carcinoma, Hepatocellular
 Liver Cirrhosis Antibodies  >2 publications with ALDH1L1 and Liver Cirrhosis
 Congenital Abnormalities Antibodies  >2 publications with ALDH1L1 and Congenital Abnormalities
 Necrosis Antibodies  >2 publications with ALDH1L1 and Necrosis
 Atrophy Antibodies  >1 publications with ALDH1L1 and Atrophy

Organs/Tissues associated with anti-ALDH1L1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with ALDH1L1 and Brain
 Liver Antibodies  >7 publications with ALDH1L1 and Liver
 Heart Antibodies  >2 publications with ALDH1L1 and Heart
 Lung Antibodies  >2 publications with ALDH1L1 and Lung
 Ganglia Antibodies  >1 publications with ALDH1L1 and Ganglia
 Intestine Antibodies  >1 publications with ALDH1L1 and Intestine
 Prostate Antibodies  >1 publications with ALDH1L1 and Prostate
 Mouth Antibodies  >1 publications with ALDH1L1 and Mouth
 Kidney Antibodies  >1 publications with ALDH1L1 and Kidney
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