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AMACR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS540964

BIOTIN-Conjugated alpha-methylacyl-CoA racemase isoform 1 Antibody C-epitopeRacemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AMACR, Polyclonal Antibody
Full Product Name
AMACR Antibody BIOTIN-Conjugated
Product Gene Name
Product Synonym Names
2 arylpropionyl CoA epimerase; 2 methylacyl CoA racemase; Alpha methylacyl CoA racemase; Alpha methylacyl Coenzyme A racemase; AMACR deficiency, included; CBAS4; Da1-8; EC 5.1.99.4; Macr1; Methylacyl CoA racemase alpha; P504S; RACE; RM antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
BIOTIN-Conjugated
Concentration
0.6 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
AMACR peptide (MBS542349) is used for blocking the activity of AMACR antibody (MBS540964)
Molecular Weight
43,860 Da
OMIM
214950
3D Structure
ModBase 3D Structure for Q9UHK6
Immunogen
Synthetic peptide taken within amino acid region 260-310 on human alpha-methylacyl-CoA racemase protein.
Immunoglobulin
IgG
Determinant
C-epitope
Molecular Function
alpha-methylacyl-CoA racemase activity; receptor binding; bile acid metabolic process
Subcellular Location
Cytoplasm; Peroxisome; Mitochondrion
Applications Tested/Suitable for anti-AMACR antibody
Confocal Microscopy (CM), Dot Blot (DB), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), IMM, Western Blot (WB)
Application Notes for anti-AMACR antibody
Confocal Microscopy||1:100
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:200
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500

Other Notes

Small volumes of anti-AMACR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMACR purchase

MBS540964 is an antibody targeting AMACR. Also known as AMACR Antibody BIOTIN-Conjugated. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AMACR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
alpha-methylacyl-CoA racemase isoform 1
NCBI Official Synonym Full Names
alpha-methylacyl-CoA racemase
NCBI Official Symbol
AMACR
NCBI Official Synonym Symbols
RM; RACE; CBAS4; AMACRD
UniProt Protein Name
Alpha-methylacyl-CoA racemase
UniProt Synonym Protein Names
2-methylacyl-CoA racemase
UniProt Gene Name
AMACR
UniProt Entry Name
AMACR_HUMAN
NCBI Protein Information
alpha-methylacyl-CoA racemase

NCBI Summary for AMACR

This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
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UniProt Comments for AMACR

AMACR: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Belongs to the CaiB/BaiF CoA-transferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - primary bile acid biosynthesis; Isomerase; Mitochondrial; EC 5.1.99.4

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: cytoplasm; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: alpha-methylacyl-CoA racemase activity; receptor binding

Biological Process: bile acid biosynthetic process; bile acid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase

Disease: Alpha-methylacyl-coa Racemase Deficiency; Bile Acid Synthesis Defect, Congenital, 4
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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