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AMNLS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9513342

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse… More details

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Product Overview

Online Datasheet in PDF
Product Name
AMNLS, Polyclonal Antibody
Full Product Name
AMNLS Rabbit Polyclonal Antibody
Product Gene Name
anti-AMNLS antibody
Product Synonym Gene Name
AMN, UNQ513/PRO1028
Product Synonym Names
BH6842; Protein amnionless
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
AMNLS Polyclonal Antibody detects endogenous levels of protein.
Preparation and Storage
Store at -20 degree C/1 year
Molecular Weight
47,754 Da
OMIM
261100
3D Structure
ModBase 3D Structure for Q9BXJ7
Immunogen
Synthesized peptide derived from part region of human protein
Modification
Unmodified/Total
Applications Tested/Suitable for anti-AMNLS antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AMNLS antibody
WB: 1:500-2000
ELISA: 1:5000-20000

Other Notes

Small volumes of anti-AMNLS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMNLS purchase

MBS9513342 is an antibody targeting AMNLS. Also known as AMNLS Rabbit Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AMNLS. It may not necessarily be applicable to this product.

NCBI GI #
110611172
NCBI GeneID
81693
NCBI Accession #
NP_112205.2
UniProt Primary Accession #
Q9BXJ7
UniProt Secondary Accession #
Q6UX83
UniProt Related Accession #
Q9BXJ7
GenBank Nucleotide #
NM_030943.3
NCBI Official Full Name
protein amnionless
NCBI Official Synonym Full Names
amnion associated transmembrane protein
NCBI Official Symbol
AMN
NCBI Official Synonym Symbols
PRO1028; amnionless
UniProt Protein Name
Protein amnionless
UniProt Gene Name
AMN
UniProt Entry Name
AMNLS_HUMAN
NCBI Protein Information
protein amnionless; amnionless homolog; visceral endoderm-specific type 1 transmembrane protein

UniProt Comments for AMNLS

AMN: Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm. Defects in AMN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected. 1 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: extracellular space; endocytic vesicle; apical plasma membrane; integral to membrane; plasma membrane; endosome membrane

Molecular Function: receptor binding

Biological Process: receptor-mediated endocytosis; vitamin metabolic process; cobalamin metabolic process; multicellular organismal development; cobalamin transport; Golgi to plasma membrane protein transport; lipoprotein metabolic process; excretion; water-soluble vitamin metabolic process

Disease: Megaloblastic Anemia 1
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Research Articles on AMNLS

1. Our genetic screening of 154 families of patients with inherited cobalamin malabsorption revealed population-specific mutations, mutational hotspots, and functionally distinct regions in the three causal genes: CUBN, AMN, and GIF.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMNLS antibody

 Reference Product  PubMed Publications
 ABCD3 antibody  >2 publications with AMNLS and ABCD3

Pathways associated with anti-AMNLS antibody

 Products by Pathway  Pathway Diagram
 Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway antibodies  Cobalamin (Cbl, Vitamin B12) Transport And Metabolism Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies  Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
 Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies  Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram

Diseases associated with anti-AMNLS antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >196 publications with AMNLS and Nervous System Diseases
 Kidney Diseases Antibodies  >33 publications with AMNLS and Kidney Diseases
 Necrosis Antibodies  >25 publications with AMNLS and Necrosis
 Hypertrophy Antibodies  >25 publications with AMNLS and Hypertrophy
 MEGALOBLASTIC ANEMIA 1 Antibodies  >25 publications with AMNLS and MEGALOBLASTIC ANEMIA 1
 Spinal Cord Diseases Antibodies  >23 publications with AMNLS and Spinal Cord Diseases
 Congenital Abnormalities Antibodies  >23 publications with AMNLS and Congenital Abnormalities
 Peripheral Nervous System Diseases Antibodies  >21 publications with AMNLS and Peripheral Nervous System Diseases
 Disease Models, Animal Antibodies  >20 publications with AMNLS and Disease Models, Animal
 Memory Disorders Antibodies  >12 publications with AMNLS and Memory Disorders

Organs/Tissues associated with anti-AMNLS antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >220 publications with AMNLS and Heart
 Muscle Antibodies  >96 publications with AMNLS and Muscle
 Kidney Antibodies  >43 publications with AMNLS and Kidney
 Intestine Antibodies  >19 publications with AMNLS and Intestine
 Testis Antibodies  >11 publications with AMNLS and Testis
 Lung Antibodies  >8 publications with AMNLS and Lung
 Stomach Antibodies  >4 publications with AMNLS and Stomach
 Pancreas Antibodies  >3 publications with AMNLS and Pancreas
 Lymph Node Antibodies  >2 publications with AMNLS and Lymph Node
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