AP1G2 Antibody – Rabbit Polyclonal

Adaptins are subunits of adaptor protein (AP) complexes involved in the formation of intracellular transport vesicles and the selection of cargo for incorporation into the vesicles. Five types of adaptor protein complexes (AP1 to AP5) have been identified with conserved heterotetramer structural composition, containing two large subunits (gamma/alpha/delta/epsilon/zeta-and beta-adaptin), one medium subunit (u-adaptin), and one small subunit (sigma-adaptin), but with distinct subcellular localizations and functions. AP1 localizes to the TGN and functions in multiple trafficking pathways to endosome, lysosome/vacuole, and basolateral domain in epithelial cells. AP2 mediates clathrin-dependent endocytosis at the plasma membrane (PM). AP3 functions in the trafficking pathway from TGN to lysosome and lysosome-related organelles. AP4 has been poorly studied, but appears to be involved in trafficking of amyloid precursor protein from the TGN to endosomes. Recently, a fifth AP complex, AP5, was discovered and localized to the late endosome in HeLa cells.

Wang X, et al. (2014) Trans-golgi network-located ap1 gamma adaptins mediate dileucine motif-directed vacuolar targeting in arabidopsis. Plant Cell 26 (10): 4102-4118.Boehm M, et al. (2001) Adaptins: The final recount. Mol Biol Cell 12 (10): 2907-2920.

Small volumes of anti-AP1G2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8110266 is an antibody targeting AP1G2. Also known as Anti-AP1G2 Antibody, Rabbit Polyclonal. Reactive in Human. Host: Rabbit.