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BHLH3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6278336

BHLHE41 may be a transcriptional repressor that represses both basal and activated transcription. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BHLH3, Polyclonal Antibody
Full Product Name
BHLH3, NT (BHLHE41, BHLHB3, DEC2, SHARP1, Class E basic helix-loop-helix protein 41, Class B basic helix-loop-helix protein 3, Differentially expressed in chondrocytes protein 2, Enhancer-of-split and hairy-related protein 1) (MaxLight 550)
Product Gene Name
anti-BHLH3 antibody
Product Synonym Gene Name
BHLHE41
Product Synonym Names
BHLHE41; BHLHB3; DEC2; SHARP1; Class E basic helix-loop-helix protein 41; Class B basic helix-loop-helix protein 3; Differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
50kDa
OMIM
606200
3D Structure
ModBase 3D Structure for Q9C0J9
Immunogen
BHLH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-54 amino acids from the N-terminal region of human BHLH3.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-BHLH3 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-BHLH3 antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-BHLH3 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-BHLH3 antibody

Honma, S., et al. Nature 419(6909):841-844(2002). Garriga-Canut, M., et al. J. Biol. Chem. 276(18):14821-14828(2001). Fujimoto, K., et al. Biochem. Biophys. Res. Commun. 280(1):164-171(2001). Grottke, C., et al. Int. J. Cancer 88(4):535-546(2000).

Other Notes

Small volumes of anti-BHLH3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BHLH3 purchase

MBS6278336 is an antibody targeting BHLH3. Also known as BHLH3, NT (BHLHE41, BHLHB3, DEC2, SHARP1, Class E basic helix-loop-helix protein 41, Class B basic helix-loop-helix protein 3, Differentially expressed in chondrocytes protein 2, Enhancer-of-split and hairy-related protein 1) (MaxLight 550). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BHLH3. It may not necessarily be applicable to this product.

NCBI GI #
13540521
NCBI GeneID
79365
NCBI Accession #
NP_110389
UniProt Primary Accession #
Q9C0J9
UniProt Related Accession #
Q9C0J9
GenBank Nucleotide #
NM_030762
NCBI Official Full Name
class E basic helix-loop-helix protein 41
NCBI Official Synonym Full Names
basic helix-loop-helix family member e41
NCBI Official Symbol
BHLHE41
NCBI Official Synonym Symbols
DEC2; hDEC2; BHLHB3; SHARP1
UniProt Protein Name
Class E basic helix-loop-helix protein 41
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 3; bHLHb3; Differentially expressed in chondrocytes protein 2; hDEC2; Enhancer-of-split and hairy-related protein 1
Protein Family
Transcription factor
UniProt Gene Name
BHLHE41
UniProt Synonym Gene Names
BHLHB3; DEC2; SHARP1; bHLHe41; bHLHb3; hDEC2; SHARP-1
UniProt Entry Name
BHE41_HUMAN
NCBI Protein Information
class E basic helix-loop-helix protein 41

NCBI Summary for BHLH3

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014]
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UniProt Comments for BHLH3

BHLHB3: May be a transcriptional repressor that represses both basal and activated transcription. Homodimerize.

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; MRF binding; protein binding; protein homodimerization activity; protein heterodimerization activity; histone deacetylase binding; bHLH transcription factor binding; transcription corepressor activity

Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; cell proliferation; organ morphogenesis; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; cell differentiation

Disease: Short Sleeper
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Research Articles on BHLH3

1. Suppression of SHARP1 induces robust apoptosis of human MLL-AF6 Acute Myeloid Leukemia cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BHLH3 antibody

 Reference Product  PubMed Publications
 BHLHE40 antibody  >11 publications with BHLH3 and BHLHE40
 MYOD1 antibody  >1 publications with BHLH3 and MYOD1

Pathways associated with anti-BHLH3 antibody

 Products by Pathway  Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram

Diseases associated with anti-BHLH3 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with BHLH3 and Breast Neoplasms
 Nervous System Diseases Antibodies  >4 publications with BHLH3 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >3 publications with BHLH3 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >2 publications with BHLH3 and Lung Neoplasms
 Endometrial Neoplasms Antibodies  >1 publications with BHLH3 and Endometrial Neoplasms
 Hypertension Antibodies  >1 publications with BHLH3 and Hypertension
 Depressive Disorder Antibodies  >1 publications with BHLH3 and Depressive Disorder
 Cardiovascular Diseases Antibodies  >1 publications with BHLH3 and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with BHLH3 and Hyperplasia
 Inflammation Antibodies  >1 publications with BHLH3 and Inflammation

Organs/Tissues associated with anti-BHLH3 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with BHLH3 and Liver
 Kidney Antibodies  >3 publications with BHLH3 and Kidney
 Vascular Antibodies  >3 publications with BHLH3 and Vascular
 Brain Antibodies  >3 publications with BHLH3 and Brain
 Lung Antibodies  >2 publications with BHLH3 and Lung
 Muscle Antibodies  >2 publications with BHLH3 and Muscle
 Heart Antibodies  >1 publications with BHLH3 and Heart
 Connective Tissue Antibodies  >1 publications with BHLH3 and Connective Tissue
 Lymph Node Antibodies  >1 publications with BHLH3 and Lymph Node
 Eye Antibodies  >1 publications with BHLH3 and Eye
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