BLM Antibody – Rabbit Polyclonal

BLM: a magnesium-dependent ATP-dependent DNA-helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. A member of the RecQ helicase family that is required for genome stability. Participates in DNA replication, recombination and repair. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex which is a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ubiquitinated FANCD2.

Protein type: DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 7 D2|7 45.65 cM

Cellular Component: chromosome, telomeric region; cytoplasm; cytosol; intracellular; lateral element; male germ cell nucleus; nuclear chromosome; nuclear matrix; nucleolus; nucleus; PML body; pronucleus; replication fork

Molecular Function: ATP binding; ATP-dependent 3'-5' DNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent helicase activity; ATPase activity; bubble DNA binding; catalytic activity; DNA binding; DNA helicase activity; DNA-dependent ATPase activity; forked DNA-dependent helicase activity; four-way junction DNA binding; four-way junction helicase activity; G-quadruplex DNA binding; helicase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding; nucleic acid binding; nucleotide binding; p53 binding; protein binding; protein homodimerization activity; single-stranded DNA binding; telomeric D-loop binding; Y-form DNA binding; zinc ion binding

Biological Process: alpha-beta T cell differentiation; cellular metabolic process; cellular response to DNA damage stimulus; cellular response to ionizing radiation; chromosome organization and biogenesis; DNA double-strand break processing; DNA duplex unwinding; DNA recombination; DNA repair; DNA replication; G-quadruplex DNA unwinding; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of cell division; negative regulation of DNA recombination; negative regulation of mitotic recombination; positive regulation of alpha-beta T cell proliferation; positive regulation of double-strand break repair via homologous recombination; positive regulation of transcription, DNA-templated; protein homooligomerization; protein oligomerization; regulation of binding; regulation of cyclin-dependent protein kinase activity; regulation of DNA-dependent DNA replication; replication fork processing; replication-born double-strand break repair via sister chromatid exchange; response to X-ray; telomere maintenance; telomeric D-loop disassembly