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BMPR1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9204562

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1… More details

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Product Overview

Online Datasheet in PDF
Product Name
BMPR1A, Polyclonal Antibody
Full Product Name
BMPR1A Antibody (Center C180)
Product Gene Name
anti-BMPR1A antibody
Product Synonym Names
Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD292; BMPR1A; ACVRLK3; ALK3
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 2 (lot specific)
Specificity
This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-195 amino acids from the Central region of human BMPR1A.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
BMPR1A peptide (MBS9224470) is used for blocking the activity of BMPR1A antibody (MBS9204562)
Molecular Weight
60198
Immunogen Sequence Positions
166-195
OMIM
174900
3D Structure
ModBase 3D Structure for P36894
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-BMPR1A antibody

Cardiovascular; Metabolism; Signal transduction
Applications Tested/Suitable for anti-BMPR1A antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-BMPR1A antibody
WB~~1:1000

Western Blot (WB) of anti-BMPR1A antibody

BMPR1A -C180 western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BMPR1A antibody detected the BMPR1A protein (arrow).
Rabbit Anti-BMPR1A Polyclonal Antibody – Cat# MBS9204562

Immunohistochemistry (IHC) of anti-BMPR1A antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-BMPR1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9204562

Product References and Citations for anti-BMPR1A antibody

Zhou, X.-P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001).
Howe, J.R., et al., Nat. Genet. 28(2):184-187 (2001).
ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).

Other Notes

Small volumes of anti-BMPR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMPR1A purchase

MBS9204562 is an antibody targeting BMPR1A. Also known as BMPR1A Antibody (Center C180). Reactive in Human, mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BMPR1A. It may not necessarily be applicable to this product.

NCBI GI #
41349437
NCBI GeneID
657
NCBI Accession #
NP_004320.2
UniProt Primary Accession #
P36894
UniProt Secondary Accession #
Q8NEN8; A8K6U9
UniProt Related Accession #
P36894
GenBank Nucleotide #
NM_004329.2
NCBI Official Full Name
bone morphogenetic protein receptor type-1A
NCBI Official Synonym Full Names
bone morphogenetic protein receptor, type IA
NCBI Official Symbol
BMPR1A
NCBI Official Synonym Symbols
ALK3; SKR5; CD292; ACVRLK3; 10q23del
UniProt Protein Name
Bone morphogenetic protein receptor type-1A
UniProt Synonym Protein Names
Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
BMPR1A
UniProt Synonym Gene Names
ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5
UniProt Entry Name
BMR1A_HUMAN
NCBI Protein Information
bone morphogenetic protein receptor type-1A

UniProt Comments for BMPR1A

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Kinase, protein; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: cell soma; dendrite; integral to membrane; plasma membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; metal ion binding; SMAD binding; ATP binding; transmembrane receptor protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: transcription from RNA polymerase II promoter; neural plate mediolateral pattern formation; hindlimb morphogenesis; developmental growth; neural crest cell development; positive regulation of transcription, DNA-dependent; mesendoderm development; paraxial mesoderm structural organization; dorsal/ventral axis specification; palate development; protein amino acid phosphorylation; negative regulation of neurogenesis; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; ectoderm development; Mullerian duct regression; somitogenesis; in utero embryonic development; lateral mesoderm development; stem cell maintenance; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; mesoderm formation; pituitary gland development; cartilage development; embryonic organ development; immune response; embryonic digit morphogenesis; positive regulation of epithelial cell proliferation; regulation of lateral mesodermal cell fate specification; lung development

Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
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Research Articles on BMPR1A

1. Results support a novel role for miR-885-3p in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BMPR1A antibody

 Reference Product  PubMed Publications
 BMP2 antibody  >92 publications with BMPR1A and BMP2
 BMP4 antibody  >79 publications with BMPR1A and BMP4
 SMAD1 antibody  >77 publications with BMPR1A and SMAD1
 BMP7 antibody  >36 publications with BMPR1A and BMP7
 SMAD5 antibody  >28 publications with BMPR1A and SMAD5
 BMP6 antibody  >18 publications with BMPR1A and BMP6
 GDF5 antibody  >14 publications with BMPR1A and GDF5
 SMAD6 antibody  >13 publications with BMPR1A and SMAD6
 SMAD7 antibody  >9 publications with BMPR1A and SMAD7
 ACVR2B antibody  >7 publications with BMPR1A and ACVR2B

Diseases associated with anti-BMPR1A antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >50 publications with BMPR1A and Congenital Abnormalities
 Juvenile polyposis syndrome Antibodies  >45 publications with BMPR1A and Juvenile polyposis syndrome
 Chromosome Aberrations Antibodies  >13 publications with BMPR1A and Chromosome Aberrations
 Hamartoma Syndrome, Multiple Antibodies  >11 publications with BMPR1A and Hamartoma Syndrome, Multiple
 Hyperplasia Antibodies  >10 publications with BMPR1A and Hyperplasia
 Craniofacial Abnormalities Antibodies  >10 publications with BMPR1A and Craniofacial Abnormalities
 Female Urogenital Diseases Antibodies  >9 publications with BMPR1A and Female Urogenital Diseases
 Abnormalities, Multiple Antibodies  >9 publications with BMPR1A and Abnormalities, Multiple
 Neoplasm Metastasis Antibodies  >6 publications with BMPR1A and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >6 publications with BMPR1A and Liver Neoplasms

Organs/Tissues associated with anti-BMPR1A antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >66 publications with BMPR1A and Embryonic Tissue
 Muscle Antibodies  >50 publications with BMPR1A and Muscle
 Heart Antibodies  >44 publications with BMPR1A and Heart
 Vascular Antibodies  >31 publications with BMPR1A and Vascular
 Brain Antibodies  >30 publications with BMPR1A and Brain
 Connective Tissue Antibodies  >23 publications with BMPR1A and Connective Tissue
 Ovary Antibodies  >20 publications with BMPR1A and Ovary
 Intestine Antibodies  >20 publications with BMPR1A and Intestine
 Liver Antibodies  >20 publications with BMPR1A and Liver
 Skin Antibodies  >18 publications with BMPR1A and Skin
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