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BRIP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6278905

BRIP1 is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BRIP1, Polyclonal Antibody
Full Product Name
BRIP1, NT (BRIP1, BACH1, FANCJ, Fanconi anemia group J protein, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1) (Azide free) (HRP)
Product Gene Name
anti-BRIP1 antibody
Product Synonym Names
BRIP1; BACH1; FANCJ; Fanconi anemia group J protein; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
112,476 Da
OMIM
gene 609054
3D Structure
ModBase 3D Structure for Q9BX63
Immunogen
BRIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-167 amino acids from the N-terminal region of human BRIP1.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-BRIP1 antibody

Antibodies; Fanconi Proteins
Applications Tested/Suitable for anti-BRIP1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-BRIP1 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-BRIP1 antibody

BRIP1 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the BRIP1 antibody detected the BRIP1 protein (arrow).
Rabbit Anti-BRIP1 Polyclonal Antibody – Cat# MBS6278905

Western Blot (WB) of anti-BRIP1 antibody

BRIP1 Antibody (N-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the BRIP1 antibody detected the BRIP1 protein (arrow).
Rabbit Anti-BRIP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6278905

Product References and Citations for anti-BRIP1 antibody

Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010). Bailey, S.D., et al. Diabetes Care (2010). In press: Solyom, S., et al. Fam. Cancer (2010). In press: Xie, J., et al. Oncogene 29(17):2499-2508(2010). Smith, I.M., et al. ORL J. Otorhinolaryngol. Relat. Spec. 72(1):44-50(2010).

Other Notes

Small volumes of anti-BRIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRIP1 purchase

MBS6278905 is an antibody targeting BRIP1. Also known as BRIP1, NT (BRIP1, BACH1, FANCJ, Fanconi anemia group J protein, ATP-dependent RNA helicase BRIP1, BRCA1-associated C-terminal helicase 1, BRCA1-interacting protein C-terminal helicase 1) (Azide free) (HRP). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BRIP1. It may not necessarily be applicable to this product.

NCBI GI #
301897118
NCBI GeneID
83990
NCBI Accession #
NP_114432
UniProt Primary Accession #
Q9BX63
UniProt Secondary Accession #
Q3MJE2; Q8NCI5
UniProt Related Accession #
Q9BX63
GenBank Nucleotide #
NM_032043
NCBI Official Full Name
Fanconi anemia group J protein
NCBI Official Synonym Full Names
BRCA1 interacting protein C-terminal helicase 1
NCBI Official Symbol
BRIP1
NCBI Official Synonym Symbols
OF; BACH1; FANCJ
UniProt Protein Name
Fanconi anemia group J protein
UniProt Synonym Protein Names
ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-interacting protein C-terminal helicase 1; BRCA1-interacting protein 1
Protein Family
Fanconi anemia group J protein
UniProt Gene Name
BRIP1
UniProt Synonym Gene Names
BACH1; FANCJ; Protein FACJ; BRCA1-interacting protein 1
UniProt Entry Name
FANCJ_HUMAN
NCBI Protein Information
Fanconi anemia group J protein; ATP-dependent RNA helicase BRIP1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1/BRCA2-associated helicase 1

UniProt Comments for BRIP1

BRIP1: a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described.

Protein type: Oncoprotein; Helicase; EC 3.6.4.13

Chromosomal Location of Human Ortholog: 17q22.2

Cellular Component: nuclear membrane; cytoplasm; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding; ATP binding

Biological Process: regulation of transcription from RNA polymerase II promoter; double-strand break repair; DNA damage checkpoint; DNA duplex unwinding

Disease: Fanconi Anemia, Complementation Group J; Breast Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BRIP1 antibody

 Reference Product  PubMed Publications
 BRCA1 antibody  >116 publications with BRIP1 and BRCA1
 PALB2 antibody  >65 publications with BRIP1 and PALB2
 FANCD2 antibody  >25 publications with BRIP1 and FANCD2
 FANCA antibody  >9 publications with BRIP1 and FANCA
 FANCI antibody  >9 publications with BRIP1 and FANCI
 BLM antibody  >7 publications with BRIP1 and BLM
 MLH1 antibody  >7 publications with BRIP1 and MLH1
 TOPBP1 antibody  >6 publications with BRIP1 and TOPBP1
 PMS2 antibody  >2 publications with BRIP1 and PMS2

Pathways associated with anti-BRIP1 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic Iron-sulfur Cluster Assembly Pathway antibodies  Cytosolic Iron-sulfur Cluster Assembly Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Fanconi Anemia Pathway antibodies  Fanconi Anemia Pathway Diagram
 Homologous DNA Pairing And Strand Exchange Pathway antibodies  Homologous DNA Pairing And Strand Exchange Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway antibodies  Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-BRIP1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >85 publications with BRIP1 and Breast Neoplasms
 Anemia Antibodies  >71 publications with BRIP1 and Anemia
 Fanconi Anemia Antibodies  >71 publications with BRIP1 and Fanconi Anemia
 Ovarian Neoplasms Antibodies  >33 publications with BRIP1 and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >4 publications with BRIP1 and Carcinoma, Squamous Cell
 Prostatic Neoplasms Antibodies  >4 publications with BRIP1 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >3 publications with BRIP1 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >2 publications with BRIP1 and Disease Models, Animal
 Liver Failure, Acute Antibodies  >1 publications with BRIP1 and Liver Failure, Acute
 Brain Diseases Antibodies  >1 publications with BRIP1 and Brain Diseases

Organs/Tissues associated with anti-BRIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with BRIP1 and Blood
 Prostate Antibodies  >7 publications with BRIP1 and Prostate
 Bone Antibodies  >6 publications with BRIP1 and Bone
 Bone Marrow Antibodies  >6 publications with BRIP1 and Bone Marrow
 Muscle Antibodies  >2 publications with BRIP1 and Muscle
 Mammary Gland Antibodies  >2 publications with BRIP1 and Mammary Gland
 Brain Antibodies  >1 publications with BRIP1 and Brain
 Liver Antibodies  >1 publications with BRIP1 and Liver
 Intestine Antibodies  >1 publications with BRIP1 and Intestine
 Skin Antibodies  >1 publications with BRIP1 and Skin
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