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CANX Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9410711

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein… More details

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Product Documentation
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CANX, Polyclonal Antibody
Full Product Name
CANX Antibody
Product Gene Name
anti-CANX antibody
Product Synonym Names
CNX; P90; IP90
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purity/Purification
Antigen affinity purification.
Concentration
1.9 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total CANX protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
55,598 Da
OMIM
114217
3D Structure
ModBase 3D Structure for P27824
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to a region derived from internal residues of human calnexin
Target Name
CANX

Product Categories/Family for anti-CANX antibody

Total protein Ab
Applications Tested/Suitable for anti-CANX antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CANX antibody
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Testing Data of anti-CANX antibody

Gel: 8%SDS-PAGE Lysates (from left to right): Hela cell and mouse liver tissue, 231 cell and human placenta tissue, human carcinoma of sigmoid tissue Amount of lysate: 40ug per lane Primary antibody: 1/420 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds
Rabbit Anti-CANX Polyclonal Antibody – Cat# MBS9410711

Immunohistochemistry (IHC) of anti-CANX antibody

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.
Rabbit Anti-CANX Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9410711

Other Notes

Small volumes of anti-CANX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CANX purchase

MBS9410711 is an antibody targeting CANX. Also known as CANX Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CANX. It may not necessarily be applicable to this product.

NCBI GI #
66933005
NCBI GeneID
821
NCBI Accession #
NP_001019820.1
UniProt Primary Accession #
P27824
UniProt Secondary Accession #
B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3
UniProt Related Accession #
P27824
GenBank Nucleotide #
NM_001024649.1
NCBI Official Full Name
calnexin
NCBI Official Synonym Full Names
calnexin
NCBI Official Symbol
CANX
NCBI Official Synonym Symbols
CNX; P90; IP90
UniProt Protein Name
Calnexin
UniProt Synonym Protein Names
IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
UniProt Gene Name
CANX
UniProt Entry Name
CALX_HUMAN
NCBI Protein Information
calnexin

UniProt Comments for CANX

Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Calcium-binding; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; rough endoplasmic reticulum; endoplasmic reticulum; endoplasmic reticulum lumen; dendritic spine; membrane; cell soma; axon; melanosome; ribosome

Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; carbohydrate binding; glycoprotein binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging
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Research Articles on CANX

1. Data indicate that protein tyrosine phosphatase 1B (PTP1B) association with calnexin is ubiquitin conjugating enzyme 9 (UBC9)-dependent.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CANX antibody

 Reference Product  PubMed Publications
 HLA-A antibody  >2 publications with CANX and HLA-A
 UBC antibody  >2 publications with CANX and UBC
 PDIA3 antibody  >2 publications with CANX and PDIA3

Pathways associated with anti-CANX antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Assembly Of Viral Components At The Budding Site Pathway antibodies  Assembly Of Viral Components At The Budding Site Pathway Diagram
 Calnexin/calreticulin Cycle Pathway antibodies  Calnexin/calreticulin Cycle Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-CANX antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with CANX and Adenocarcinoma
 Carcinoma Antibodies  >2 publications with CANX and Carcinoma
 Infertility, Male Antibodies  >1 publications with CANX and Infertility, Male
 Lung Diseases Antibodies  >1 publications with CANX and Lung Diseases
 Disease Models, Animal Antibodies  >1 publications with CANX and Disease Models, Animal
 Liver Diseases Antibodies  >1 publications with CANX and Liver Diseases
 Heart Diseases Antibodies  >1 publications with CANX and Heart Diseases

Organs/Tissues associated with anti-CANX antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with CANX and Lung
 Liver Antibodies  >2 publications with CANX and Liver
 Testis Antibodies  >2 publications with CANX and Testis
 Blood Antibodies  >1 publications with CANX and Blood
 Kidney Antibodies  >1 publications with CANX and Kidney
 Skin Antibodies  >1 publications with CANX and Skin
 Uterus Antibodies  >1 publications with CANX and Uterus
 Placenta Antibodies  >1 publications with CANX and Placenta
 Embryonic Tissue Antibodies  >1 publications with CANX and Embryonic Tissue
 Epididymis Antibodies  >1 publications with CANX and Epididymis
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