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CD105 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9608314

Function: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD105, Polyclonal Antibody
Full Product Name
CD105 Antibody
Product Gene Name
anti-CD105 antibody
Product Synonym Gene Name
ENG
Product Synonym Names
AI528660; AI662476; CD 105; CD105; CD105 antigen; EGLN_HUMAN; END; Endoglin; Eng; FLJ41744; HHT1; ORW; ORW1; Osler Rendu Weber syndrome 1; RP11 228B15.2; S-endoglin; SN6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
CD105 antibody detects endogenous levels of total CD105
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
CD105 peptide (MBS9627026) is used for blocking the activity of CD105 antibody (MBS9608314)
Molecular Weight
Observed: 95 kDa
Predicted: 71 kDa
3D Structure
ModBase 3D Structure for P17813
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human CD105
Subcellular Location
Membrane.
Tissue Specificity
Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830).
Predicted Cross Reactivity
Pig, Horse, Sheep, Dog
Similarity
Pig (90%), Horse (90%), Sheep (90%), Dog (80%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD105 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CD105 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-CD105 antibody

Western blot analysis of CD105 using LOVO whole lysates.
Rabbit Anti-CD105 Polyclonal Antibody – Cat# MBS9608314

Other Notes

Small volumes of anti-CD105 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD105 purchase

MBS9608314 is an antibody targeting CD105. Also known as CD105 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD105. It may not necessarily be applicable to this product.

NCBI GI #
4557555
NCBI GeneID
2022
NCBI Accession #
NP_000109.1
UniProt Primary Accession #
P17813
UniProt Secondary Accession #
Q14248; Q14926; Q5T9C0
UniProt Related Accession #
P17813
GenBank Nucleotide #
NM_000118.3
NCBI Official Full Name
endoglin isoform 2
NCBI Official Synonym Full Names
endoglin
NCBI Official Symbol
ENG
NCBI Official Synonym Symbols
END; HHT1; ORW1
UniProt Protein Name
Endoglin
UniProt Synonym Protein Names
CD_antigen: CD105
Protein Family
Endoglin
UniProt Gene Name
ENG
UniProt Synonym Gene Names
END
NCBI Protein Information
endoglin

NCBI Summary for CD105

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
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UniProt Comments for CD105

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529).
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Research Articles on CD105

1. ENG mutation carriers were more likely than ACVRL1 mutation carriers to have pAVMs (P < 0.001) or multiple lesions (P = 0.03), and to undergo procedural intervention (P = 0.02). The HHT severity score was significantly higher in ENG than in ACVRL1 (P = 0.02).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD105 antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >288 publications with CD105 and TGFB1
 ACVRL1 antibody  >135 publications with CD105 and ACVRL1
 BMP2 antibody  >103 publications with CD105 and BMP2
 SMAD4 antibody  >42 publications with CD105 and SMAD4
 HIF1A antibody  >32 publications with CD105 and HIF1A
 TGFBR2 antibody  >4 publications with CD105 and TGFBR2
 TGFBR1 antibody  >3 publications with CD105 and TGFBR1
 GIPC1 antibody  >1 publications with CD105 and GIPC1
 TGFBI antibody  >1 publications with CD105 and TGFBI

Pathways associated with anti-CD105 antibody

 Products by Pathway  Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 TGF Beta Signaling Pathway antibodies  TGF Beta Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-CD105 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5952 publications with CD105 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5124 publications with CD105 and Cardiovascular Diseases
 Neoplasms Antibodies  >3568 publications with CD105 and Neoplasms
 Heart Diseases Antibodies  >2699 publications with CD105 and Heart Diseases
 Breast Neoplasms Antibodies  >689 publications with CD105 and Breast Neoplasms
 Disease Models, Animal Antibodies  >646 publications with CD105 and Disease Models, Animal
 Hypertension Antibodies  >524 publications with CD105 and Hypertension
 Drug Toxicity Antibodies  >511 publications with CD105 and Drug Toxicity
 Inflammation Antibodies  >505 publications with CD105 and Inflammation
 Liver Diseases Antibodies  >411 publications with CD105 and Liver Diseases

Organs/Tissues associated with anti-CD105 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10044 publications with CD105 and Blood
 Heart Antibodies  >7041 publications with CD105 and Heart
 Bone Antibodies  >6758 publications with CD105 and Bone
 Brain Antibodies  >6685 publications with CD105 and Brain
 Muscle Antibodies  >6154 publications with CD105 and Muscle
 Vascular Antibodies  >6009 publications with CD105 and Vascular
 Nerve Antibodies  >2656 publications with CD105 and Nerve
 Skin Antibodies  >2537 publications with CD105 and Skin
 Connective Tissue Antibodies  >2076 publications with CD105 and Connective Tissue
 Eye Antibodies  >1771 publications with CD105 and Eye
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