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CD2BP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9211791

This gene encodes a bi-functional protein. In thecytoplasm, the encoded protein binds the cytoplasmic tail of humansurface antigen CD2 via its C-terminal GYF domain, and regulateCD2-triggered T lymphocyte activation. In the nucleus, this proteinis a component… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD2BP2, Polyclonal Antibody
Full Product Name
CD2BP2 Antibody (N-term)
Product Gene Name
Product Synonym Names
CD2 antigen cytoplasmic tail-binding protein 2; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; U5 snRNP 52K protein; U5-52K; CD2BP2; KIAA1178
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This CD2BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-52 amino acids from the N-terminal region of human CD2BP2.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CD2BP2 peptide (MBS9218000) is used for blocking the activity of CD2BP2 antibody (MBS9211791)
Molecular Weight
37646
Immunogen Sequence Positions
24-52
OMIM
604470
3D Structure
ModBase 3D Structure for O95400
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN

Product Categories/Family for anti-CD2BP2 antibody

Applications Tested/Suitable for anti-CD2BP2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-CD2BP2 antibody
WB~~1:1000

Western Blot (WB) of anti-CD2BP2 antibody

CD2BP2 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the CD2BP2 antibody detected the CD2BP2 protein (arrow).
Rabbit Anti-CD2BP2 Polyclonal Antibody – Cat# MBS9211791

Immunohistochemistry (IHC) of anti-CD2BP2 antibody

CD2BP2 antibody(N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CD2BP2 antibody(N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CD2BP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9211791

Flow Cytometry (FC/FACS) of anti-CD2BP2 antibody

CD2BP2 Antibody (N-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CD2BP2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9211791

Product References and Citations for anti-CD2BP2 antibody

Heinze, M., et al. Int. Immunol. 19(11):1313-1318(2007)
Nielsen, T.K., et al. J. Mol. Biol. 369(4):902-908(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Al-Dhaheri, M.H., et al. Steroids 71 (11-12), 966-978 (2006) :

Other Notes

Small volumes of anti-CD2BP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD2BP2 purchase

MBS9211791 is an antibody targeting CD2BP2. Also known as CD2BP2 Antibody (N-term). Reactive in Human (Predicted Reactivity: Mouse). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD2BP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
CD2 antigen cytoplasmic tail-binding protein 2
NCBI Official Synonym Full Names
CD2 (cytoplasmic tail) binding protein 2
NCBI Official Symbol
CD2BP2
NCBI Official Synonym Symbols
LIN1; Snu40; FWP010; U5-52K; PPP1R59
UniProt Protein Name
CD2 antigen cytoplasmic tail-binding protein 2
UniProt Synonym Protein Names
U5 snRNP 52K protein; U5-52K
UniProt Gene Name
CD2BP2
UniProt Synonym Gene Names
KIAA1178; CD2 cytoplasmic domain-binding protein 2; CD2 tail-binding protein 2; U5-52K
UniProt Entry Name
CD2B2_HUMAN
NCBI Protein Information
CD2 antigen cytoplasmic tail-binding protein 2

NCBI Summary for CD2BP2

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
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UniProt Comments for CD2BP2

CD2BP2: Binds the cytoplasmic domain of CD2 through the GYF domain.

Protein type: Spliceosome; RNA processing; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; U4/U6 x U5 tri-snRNP complex; snRNP U5; cytoplasm; nuclear speck; nucleus

Molecular Function: ribonucleoprotein binding; protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; RNA splicing; gene expression
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD2BP2 antibody

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