• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Gamma (CD3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS541213

FITC-Conjugated T-cell surface glycoprotein CD3 gamma chain AntibodyThe CD3 complex mediates signal transduction. More details

$610 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD3 Gamma, Polyclonal Antibody
Full Product Name
CD3 Gamma Antibody FITC-Conjugated
Product Gene Name
anti-CD3 antibody
Product Synonym Names
CD3 gamma; CD3g; CD3g antigen gamma polypeptide (TiT3 complex); CD3g antigen gamma polypeptide; CD3g molecule gamma (CD3 TCR complex); T-cell receptor T3 gamma chain; T-cell surface glycoprotein CD3 gamma chain; T3G antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
FITC-Conjugated
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)
Preparation and Storage
-20 degree C for long term storage
Matching Pairs
Antibody: CD3 Gamma (MBS541213)
Positive Control: CD3 Gamma (MBS542619)
Antibody/Peptide Pairs
CD3 Gamma peptide (MBS542688) is used for blocking the activity of CD3 Gamma antibody (MBS541213)
Molecular Weight
20,469 Da
OMIM
186740
3D Structure
ModBase 3D Structure for P09693
Immunogen
Synthetic peptide taken within amino acid region 131-181 on human T-cell surface glycoprotein CD3 gamma protein.
Molecular Function
Protein heterodimerization activity; T cell receptor binding; Receptor signaling complex scaffold activity; Transmembrane signaling receptor activity
Structure
The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
Subcellular Location
Membrane; Single-pass type I membrane protein
Applications Tested/Suitable for anti-CD3 antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes for anti-CD3 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500

Other Notes

Small volumes of anti-CD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD3 purchase

MBS541213 is an antibody targeting CD3. Also known as CD3 Gamma Antibody FITC-Conjugated. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD3. It may not necessarily be applicable to this product.

NCBI GI #
4557429
NCBI GeneID
917
NCBI Accession #
NP_000064.1
UniProt Primary Accession #
P09693
UniProt Secondary Accession #
Q2HIZ6
UniProt Related Accession #
P09693
GenBank Nucleotide #
NM_000073.2
NCBI Official Full Name
T-cell surface glycoprotein CD3 gamma chain
NCBI Official Synonym Full Names
CD3g molecule
NCBI Official Symbol
CD3G
NCBI Official Synonym Symbols
T3G; IMD17; CD3-GAMMA
UniProt Protein Name
T-cell surface glycoprotein CD3 gamma chain
UniProt Synonym Protein Names
T-cell receptor T3 gamma chain; CD_antigen: CD3g
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD3G
UniProt Synonym Gene Names
T3G
UniProt Entry Name
CD3G_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD3 gamma chain

NCBI Summary for CD3

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CD3

CD3G: The CD3 complex mediates signal transduction.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: alpha-beta T cell receptor complex; integral to plasma membrane; plasma membrane; T cell receptor complex

Molecular Function: protein heterodimerization activity; receptor signaling complex scaffold activity; T cell receptor binding; transmembrane receptor activity

Biological Process: cell surface receptor linked signal transduction; establishment and/or maintenance of cell polarity; protein complex assembly; protein transport; regulation of immune response; T cell activation; T cell costimulation; T cell receptor signaling pathway

Disease: Immunodeficiency 17
Show more

Research Articles on CD3

1. The study identifies an important role of the CD3gamma dileucine motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Downstream TCR Signaling Pathway antibodies  Downstream TCR Signaling Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram

Diseases associated with anti-CD3 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with CD3 and Cardiovascular Diseases
 Inflammation Antibodies  >4 publications with CD3 and Inflammation
 Heart Diseases Antibodies  >2 publications with CD3 and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with CD3 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with CD3 and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with CD3 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with CD3 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >1 publications with CD3 and Kidney Diseases

Organs/Tissues associated with anti-CD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with CD3 and Blood
 Thymus Antibodies  >3 publications with CD3 and Thymus
 Testis Antibodies  >1 publications with CD3 and Testis
 Brain Antibodies  >1 publications with CD3 and Brain
 Spleen Antibodies  >1 publications with CD3 and Spleen
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000