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CENPJ Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9603843

Function: Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CENPJ, Polyclonal Antibody
Full Product Name
CENPJ Antibody
Product Gene Name
anti-CENPJ antibody
Product Synonym Names
BM032; CENP-J; CENPJ; CENPJ_HUMAN; Centromere protein J; Centrosomal P4.1-associated protein; CPAP; LAG-3-associated protein; LAP; LIP1; LYST interacting protein LIP1; LYST interacting protein LIP7; LYST-interacting protein 1; MCPH6; Sas 4; SASS4; SCKL4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
CENPJ antibody detects endogenous levels of total CENPJ
Antibody/Peptide Pairs
CENPJ peptide (MBS9622561) is used for blocking the activity of CENPJ antibody (MBS9603843)
Molecular Weight
Observed: 149 kDa
Predicted: 153 kDa
3D Structure
ModBase 3D Structure for Q9HC77
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Cytoplasm > Cytoskeleton > Centrosome. Cytoplasm > Cytoskeleton > Centrosome > Centriole. Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
Predicted Cross Reactivity
Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Similarity
Pig (92%), Zebrafish (83%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (83%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CENPJ antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CENPJ antibody
WB: 1:500-1:2000

Western Blot (WB) of anti-CENPJ antibody

Western blot analysis of CENPJ expression in Jurkat cell lysate, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-CENPJ Polyclonal Antibody – Cat# MBS9603843

Other Notes

Small volumes of anti-CENPJ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CENPJ purchase

MBS9603843 is an antibody targeting CENPJ. Also known as CENPJ Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CENPJ. It may not necessarily be applicable to this product.

NCBI GI #
130980075
NCBI GeneID
55835
NCBI Accession #
NP_060921.3
UniProt Primary Accession #
Q9HC77
UniProt Secondary Accession #
Q2KHM6; Q5JPD5; Q5T6R5; Q96KS5; Q9C067
UniProt Related Accession #
Q9HC77
GenBank Nucleotide #
NM_018451.4
NCBI Official Full Name
centromere protein J
NCBI Official Synonym Full Names
centromere protein J
NCBI Official Symbol
CENPJ
NCBI Official Synonym Symbols
LAP; CPAP; LIP1; BM032; MCPH6; SASS4; SCKL4; Sas-4; CENP-J
UniProt Protein Name
Centromere protein J
UniProt Synonym Protein Names
Centrosomal P4.1-associated protein; LAG-3-associated protein; LYST-interacting protein 1
Protein Family
Centromere protein
UniProt Gene Name
CENPJ
UniProt Synonym Gene Names
CPAP; LAP; LIP1; CENP-J
NCBI Protein Information
centromere protein J

NCBI Summary for CENPJ

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
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UniProt Comments for CENPJ

Plays an important role in cell division and centrosome function by participating in centriole duplication (PubMed:17681131, PubMed:20531387). Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles (PubMed:15047868, PubMed:27219064, PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865). May be involved in the control of centriolar-microtubule growth by acting as a regulator of tubulin release (PubMed:27306797).
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Research Articles on CENPJ

1. CPAP regulates delivery of its bound beta-tubulin to define the size of microtubule-based cellular structures using a "clutch-like" mechanism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CENPJ antibody

 Reference Product  PubMed Publications
 STAT5B antibody  >1 publications with CENPJ and STAT5B
 STAT5A antibody  >1 publications with CENPJ and STAT5A

Pathways associated with anti-CENPJ antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway antibodies  Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway Diagram

Diseases associated with anti-CENPJ antibody

 Disease Name  Pubmed Publications
 Nervous System Malformations Antibodies  >11 publications with CENPJ and Nervous System Malformations
 MICROCEPHALY 6, PRIMARY, AUTOSOMAL RECESSIVE Antibodies  >2 publications with CENPJ and MICROCEPHALY 6, PRIMARY, AUTOSOMAL RECESSIVE
 Breast Neoplasms Antibodies  >1 publications with CENPJ and Breast Neoplasms
 Adenocarcinoma Antibodies  >1 publications with CENPJ and Adenocarcinoma

Organs/Tissues associated with anti-CENPJ antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with CENPJ and Brain
 Bone Antibodies  >1 publications with CENPJ and Bone
 Blood Antibodies  >1 publications with CENPJ and Blood
 Mammary Gland Antibodies  >1 publications with CENPJ and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with CENPJ and Embryonic Tissue
 Bone Marrow Antibodies  >1 publications with CENPJ and Bone Marrow
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