CETP Antibody – Rabbit Polyclonal

The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

CETP: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1). Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Vesicle; Secreted, signal peptide; Lipid-binding

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: extracellular region; extracellular space; vesicle

Molecular Function: cholesterol binding; cholesterol transporter activity; lipid binding; lipid transporter activity; phosphatidylcholine binding; phospholipid transporter activity; triglyceride binding

Biological Process: cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; lipid homeostasis; lipid transport; lipoprotein metabolic process; phosphatidylcholine metabolic process; phospholipid homeostasis; phospholipid transport; receptor-mediated endocytosis; reverse cholesterol transport; triacylglycerol metabolic process; triacylglycerol transport

Disease: Hyperalphalipoproteinemia 1