Rabbit Anti-CFTR Polyclonal Antibody – Cat# MBS9128142

Western blot analysis of extracts of HL-60 cells, using CFTR antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 60s.

CFTR Antibody – Rabbit Polyclonal

Name: CFTR Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9128142
Price: 225 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9128142

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP,… More details

$225 / 0.02 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CFTR, Polyclonal Antibody

Full Product Name

CFTR Polyclonal Antibody

Product Gene Name

anti-CFTR antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Purity/Purification

Affinity Purification

Preparation and Storage

Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

168kDa

OMIM

219700

3D Structure

ModBase 3D Structure for P13569

Immunogen

Recombinant protein of human CFTR

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CFTR antibody

Western Blot (WB)

Application Notes for anti-CFTR antibody

WB 1:500 - 1:2000

Other Notes

Small volumes of anti-CFTR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CFTR purchase

MBS9128142 is an antibody targeting CFTR. Also known as CFTR Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CFTR. It may not necessarily be applicable to this product.

NCBI GI #

90421313

NCBI GeneID

1080

NCBI Accession #

NP_000483.3

UniProt Primary Accession #

P13569

UniProt Secondary Accession #

Q20BG8; Q20BH2; Q2I0A1; Q2I102

UniProt Related Accession #

P13569

GenBank Nucleotide #

NM_000492.3

NCBI Official Full Name

cystic fibrosis transmembrane conductance regulator

NCBI Official Synonym Full Names

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

NCBI Official Symbol

CFTR

NCBI Official Synonym Symbols

CF; MRP7; ABC35; ABCC7; CFTR/MRP; TNR-CFTR; dJ760C5.1

UniProt Protein Name

Cystic fibrosis transmembrane conductance regulator

UniProt Synonym Protein Names

ATP-binding cassette sub-family C member 7; Channel conductance-controlling ATPase (EC:3.6.3.49); cAMP-dependent chloride channel

Protein Family

Cystic fibrosis transmembrane conductance regulator

UniProt Gene Name

CFTR

UniProt Synonym Gene Names

ABCC7; CFTR

UniProt Entry Name

CFTR_HUMAN

NCBI Protein Information

cystic fibrosis transmembrane conductance regulator

UniProt Comments for CFTR

CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice

Protein type: EC 3.6.3.49; Transporter, ABC family; Membrane protein, multi-pass; Hydrolase; Transporter; Channel, chloride; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: recycling endosome; microvillus; protein complex; cytoplasmic vesicle membrane; cell surface; basolateral plasma membrane; early endosome membrane; apical plasma membrane; early endosome; cytoplasm; plasma membrane

Molecular Function: bicarbonate transmembrane transporter activity; chloride channel activity; protein binding; enzyme binding; chloride channel inhibitor activity; chloride transmembrane transporter activity; channel-conductance-controlling ATPase activity; ATP-binding and phosphorylation-dependent chloride channel activity; ATP binding; PDZ domain binding

Biological Process: intracellular pH elevation; response to drug; response to peptide hormone stimulus; cholesterol transport; iodide transport; water transport; transepithelial chloride transport; membrane hyperpolarization; respiratory gaseous exchange; positive regulation of vasodilation; cholesterol biosynthetic process; vasodilation; cellular response to hormone stimulus; transport; response to estrogen stimulus; bicarbonate transport; response to cytokine stimulus; transmembrane transport; sperm capacitation; lung development

Disease: Vas Deferens, Congenital Bilateral Aplasia Of; Bronchiectasis With Or Without Elevated Sweat Chloride 1; Cystic Fibrosis; Pancreatitis, Hereditary

Research Articles on CFTR

1. Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CFTR antibody

Reference Product	PubMed Publications
ANO1 antibody	>28 publications with CFTR and ANO1
HSPA8 antibody	>15 publications with CFTR and HSPA8
UBC antibody	>10 publications with CFTR and UBC
STUB1 antibody	>9 publications with CFTR and STUB1
VCP antibody	>7 publications with CFTR and VCP
DNAJA1 antibody	>4 publications with CFTR and DNAJA1
SLC9A3R2 antibody	>2 publications with CFTR and SLC9A3R2
SLC9A3R1 antibody	>1 publications with CFTR and SLC9A3R1

Pathways associated with anti-CFTR antibody

Products by Pathway	Pathway Diagram
ABC Transporter Disorders Pathway antibodies	ABC Transporter Disorders Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC Transporters Pathway antibodies	ABC Transporters Pathway Diagram
ABC-family Proteins Mediated Transport Pathway antibodies	ABC-family Proteins Mediated Transport Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Defective CFTR Causes Cystic Fibrosis Pathway antibodies	Defective CFTR Causes Cystic Fibrosis Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram

Diseases associated with anti-CFTR antibody

Disease Name	Pubmed Publications
Fibrosis Antibodies	>8151 publications with CFTR and Fibrosis
Cystic Fibrosis Antibodies	>8142 publications with CFTR and Cystic Fibrosis
Lung Diseases Antibodies	>4490 publications with CFTR and Lung Diseases
Inflammation Antibodies	>590 publications with CFTR and Inflammation
Disease Models, Animal Antibodies	>368 publications with CFTR and Disease Models, Animal
Pancreatitis Antibodies	>364 publications with CFTR and Pancreatitis
Infertility, Male Antibodies	>301 publications with CFTR and Infertility, Male
Pancreatitis, Chronic Antibodies	>263 publications with CFTR and Pancreatitis, Chronic
Bronchiectasis With Or Without Elevated Sweat Chloride 1 Antibodies	>186 publications with CFTR and Bronchiectasis With Or Without Elevated Sweat Chloride 1
Liver Diseases Antibodies	>138 publications with CFTR and Liver Diseases

Organs/Tissues associated with anti-CFTR antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1758 publications with CFTR and Lung
Intestine Antibodies	>627 publications with CFTR and Intestine
Pancreas Antibodies	>457 publications with CFTR and Pancreas
Kidney Antibodies	>392 publications with CFTR and Kidney
Liver Antibodies	>340 publications with CFTR and Liver
Trachea Antibodies	>259 publications with CFTR and Trachea
Muscle Antibodies	>184 publications with CFTR and Muscle
Brain Antibodies	>95 publications with CFTR and Brain
Ovary Antibodies	>73 publications with CFTR and Ovary
Thyroid Antibodies	>62 publications with CFTR and Thyroid