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CHST3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6285959

CHST3 is an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CHST3, Polyclonal Antibody
Full Product Name
CHST3, NT (CHST3, Carbohydrate sulfotransferase 3, Chondroitin 6-O-sulfotransferase 1, Chondroitin 6-sulfotransferase, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (MaxLight 490)
Product Gene Name
anti-CHST3 antibody
Product Synonym Names
CHST3; Carbohydrate sulfotransferase 3; Chondroitin 6-O-sulfotransferase 1; Chondroitin 6-sulfotransferase; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CHST3. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
54,706 Da
3D Structure
ModBase 3D Structure for Q7LGC8
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 25-54 in the N-terminal region of human CHST3, UniProt Accession #NP_004264.2; Q7LGC8; Q9QZL2; O88199. Species sequence homology: rat
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-CHST3 antibody

Antibodies; Enzymes; Sulfotransferase
Applications Tested/Suitable for anti-CHST3 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-CHST3 antibody
IHC: 1:50-100
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CHST3 antibody

Western Blot analysis in mouse spleen and lung tissue lysates (35ug/lane) usingMBS6012094. This demonstrates that MBS6012094 detected the CHST3 protein (arrow).
Rabbit Anti-CHST3 Polyclonal Antibody – Cat# MBS6285959

Immunohistochemistry (IHC) of anti-CHST3 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle using MBS6012094 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6012094 for immunohistochemistry.
Rabbit Anti-CHST3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6285959

Product References and Citations for anti-CHST3 antibody

1. Unger, S., et al. Am. J. Med. Genet. A 152A (10), 2543-2549 (2010). 2. Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009). 3. Tuysuz, B., et al. Clin. Genet. 75(4):375-383(2009). 4. Kitagawa, H., et al. J. Biol. Chem. 283(41):27438-27443(2008). 5. Hermanns, P., et al. Am. J. Hum. Genet. 82(6):1368-1374(2008).

Other Notes

Small volumes of anti-CHST3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHST3 purchase

MBS6285959 is an antibody targeting CHST3. Also known as CHST3, NT (CHST3, Carbohydrate sulfotransferase 3, Chondroitin 6-O-sulfotransferase 1, Chondroitin 6-sulfotransferase, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0) (MaxLight 490). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHST3. It may not necessarily be applicable to this product.

NCBI GI #
19923281
NCBI GeneID
9469
NCBI Accession #
NP_004264.2
UniProt Primary Accession #
Q7LGC8
UniProt Secondary Accession #
Q9QZL2; O88199
UniProt Related Accession #
Q7LGC8
GenBank Nucleotide #
NM_004273.4
NCBI Official Full Name
carbohydrate sulfotransferase 3
NCBI Official Synonym Full Names
carbohydrate sulfotransferase 3
NCBI Official Symbol
CHST3
NCBI Official Synonym Symbols
HSD; C6ST; C6ST1
UniProt Protein Name
Carbohydrate sulfotransferase 3
UniProt Synonym Protein Names
Chondroitin 6-O-sulfotransferase 1; C6ST-1; Chondroitin 6-sulfotransferase; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST-0
Protein Family
Carbohydrate sulfotransferase
UniProt Gene Name
CHST3
UniProt Synonym Gene Names
C6ST-1; GST-0
NCBI Protein Information
carbohydrate sulfotransferase 3

NCBI Summary for CHST3

This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
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UniProt Comments for CHST3

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.
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Research Articles on CHST3

1. We describe three consanguineous Indian families with a distinct form of spondyloepiphyseal dysplasia (SED Omani type). It is an autosomal recessive disorder due to mutation in CHST3 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CHST3 antibody

 Products by Pathway  Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram

Diseases associated with anti-CHST3 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >5 publications with CHST3 and Congenital Abnormalities
 Inflammation Antibodies  >3 publications with CHST3 and Inflammation
 SPONDYLOEPIPHYSEAL DYSPLASIA WITH CONGENITAL JOINT DISLOCATIONS Antibodies  >3 publications with CHST3 and SPONDYLOEPIPHYSEAL DYSPLASIA WITH CONGENITAL JOINT DISLOCATIONS
 Neoplasms Antibodies  >2 publications with CHST3 and Neoplasms
 Drug Toxicity Antibodies  >2 publications with CHST3 and Drug Toxicity
 Cardiovascular Abnormalities Antibodies  >1 publications with CHST3 and Cardiovascular Abnormalities
 Heart Diseases Antibodies  >1 publications with CHST3 and Heart Diseases
 Necrosis Antibodies  >1 publications with CHST3 and Necrosis
 Breast Neoplasms Antibodies  >1 publications with CHST3 and Breast Neoplasms

Organs/Tissues associated with anti-CHST3 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >5 publications with CHST3 and Bone
 Vascular Antibodies  >2 publications with CHST3 and Vascular
 Embryonic Tissue Antibodies  >2 publications with CHST3 and Embryonic Tissue
 Umbilical Cord Antibodies  >1 publications with CHST3 and Umbilical Cord
 Muscle Antibodies  >1 publications with CHST3 and Muscle
 Prostate Antibodies  >1 publications with CHST3 and Prostate
 Lung Antibodies  >1 publications with CHST3 and Lung
 Kidney Antibodies  >1 publications with CHST3 and Kidney
 Skin Antibodies  >1 publications with CHST3 and Skin
 Brain Antibodies  >1 publications with CHST3 and Brain
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