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COPB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6287847

The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COPB2, Polyclonal Antibody
Full Product Name
COPB2, CT (COPB2, Coatomer subunit beta', Beta'-coat protein, p102) (Biotin)
Product Gene Name
anti-COPB2 antibody
Product Synonym Names
COPB2; Coatomer subunit beta'; Beta'-coat protein; p102
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
Predicted MW: 105.919kDa
3D Structure
ModBase 3D Structure for P35606
Immunogen
COPB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 814-843 amino acids from the C-terminal region of human COPB2.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-COPB2 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-COPB2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-COPB2 antibody
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-COPB2 antibody

COPB2 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the COPB2 antibody detected the COPB2 protein (arrow).
Rabbit Anti-COPB2 Polyclonal Antibody – Cat# MBS6287847

Western Blot (WB) of anti-COPB2 antibody

COPB2 Antibody (C-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the COPB2 antibody detected the COPB2 protein (arrow).
Rabbit Anti-COPB2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6287847

Product References and Citations for anti-COPB2 antibody

Kim, E., et al. Biochem. Biophys. Res. Commun. 395(2):244-250(2010). Guo, Y., et al. Mol. Biol. Cell 19(7):2830-2843(2008). Rikova, K., et al. Cell 131(6):1190-1203(2007). Tu, L.C., et al. Mol. Cell Proteomics 6(4):575-588(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007).

Other Notes

Small volumes of anti-COPB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COPB2 purchase

MBS6287847 is an antibody targeting COPB2. Also known as COPB2, CT (COPB2, Coatomer subunit beta', Beta'-coat protein, p102) (Biotin). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COPB2. It may not necessarily be applicable to this product.

NCBI GI #
4758032
NCBI GeneID
9276
NCBI Accession #
NP_004757.1
UniProt Primary Accession #
P35606
UniProt Secondary Accession #
B4DZI8
UniProt Related Accession #
P35606
GenBank Nucleotide #
NM_004766.2
NCBI Official Full Name
coatomer subunit beta'
NCBI Official Synonym Full Names
coatomer protein complex subunit beta 2
NCBI Official Symbol
COPB2
NCBI Official Synonym Symbols
MCPH19; beta'-COP
UniProt Protein Name
Coatomer subunit beta'
UniProt Synonym Protein Names
Beta'-coat protein; Beta'-COP; p102
UniProt Gene Name
COPB2
UniProt Synonym Gene Names
Beta'-COP
NCBI Protein Information
coatomer subunit beta'

UniProt Comments for COPB2

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors ().
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Research Articles on COPB2

1. The increased expression of COPB2 was significantly correlated with the progression of lung adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COPB2 antibody

 Reference Product  PubMed Publications
 COPA antibody  >1 publications with COPB2 and COPA

Pathways associated with anti-COPB2 antibody

 Products by Pathway  Pathway Diagram
 COPI Mediated Transport Pathway antibodies  COPI Mediated Transport Pathway Diagram
 Golgi To ER Retrograde Transport Pathway antibodies  Golgi To ER Retrograde Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram

Diseases associated with anti-COPB2 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >1 publications with COPB2 and Lung Neoplasms
 Breast Neoplasms Antibodies  >1 publications with COPB2 and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with COPB2 and Carcinoma
 Cardiovascular Diseases Antibodies  >1 publications with COPB2 and Cardiovascular Diseases
 Infertility, Female Antibodies  >1 publications with COPB2 and Infertility, Female
 Adenocarcinoma Antibodies  >1 publications with COPB2 and Adenocarcinoma
 Translocation, Genetic Antibodies  >1 publications with COPB2 and Translocation, Genetic
 Infertility, Male Antibodies  >1 publications with COPB2 and Infertility, Male
 Cell Transformation, Neoplastic Antibodies  >1 publications with COPB2 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-COPB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with COPB2 and Blood
 Eye Antibodies  >1 publications with COPB2 and Eye
 Prostate Antibodies  >1 publications with COPB2 and Prostate
 Pancreas Antibodies  >1 publications with COPB2 and Pancreas
 Lung Antibodies  >1 publications with COPB2 and Lung
 Testis Antibodies  >1 publications with COPB2 and Testis
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