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CTSE Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624238

CTSE is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CTSE, Polyclonal Antibody
Full Product Name
CTSE, ID (Cathepsin E, Cathepsin E form I, Cathepsin E form II)
Product Gene Name
Product Synonym Names
Anti -CTSE, ID (Cathepsin E, Cathepsin E form I, Cathepsin E form II)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human CTSE. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
43,312 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (206317459..206332104). Location: 1q31
OMIM
116890
3D Structure
ModBase 3D Structure for P14091
Immunogen
Synthetic peptide selected from the Center region of human CTSE (KLH).

Product Categories/Family for anti-CTSE antibody

Applications Tested/Suitable for anti-CTSE antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CTSE antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100

Western Blot (WB) of anti-CTSE antibody

Western blot analysis of CTSE antibody (Center) in K562 cell line lysates (35ug/lane).CTSE(arrow) was detected using the purified Pab.
Rabbit Anti-CTSE Polyclonal Antibody – Cat# MBS624238

Western Blot (WB) of anti-CTSE antibody

Western blot analysis of CTSE antibody (Center) in mouse stomach tissue lysates (35ug/lane).CTSE(arrow) was detected using the purified Pab.
Rabbit Anti-CTSE Polyclonal Antibody, Western Blot (WB) – Cat# MBS624238

Immunohistochemistry (IHC) of anti-CTSE antibody

CTSE Antibody (Center) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CTSE Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CTSE Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624238

Flow Cytometry (FC/FACS) of anti-CTSE antibody

CTSE Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CTSE Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS624238

Other Notes

Small volumes of anti-CTSE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CTSE purchase

MBS624238 is an antibody targeting CTSE. Also known as CTSE, ID (Cathepsin E, Cathepsin E form I, Cathepsin E form II). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CTSE. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cathepsin E isoform a preproprotein
NCBI Official Synonym Full Names
cathepsin E
NCBI Official Symbol
CTSE
NCBI Official Synonym Symbols
CATE
UniProt Protein Name
Cathepsin E
Protein Family
UniProt Gene Name
CTSE
UniProt Entry Name
CATE_HUMAN
NCBI Protein Information
cathepsin E; OTTHUMP00000034345; OTTHUMP00000034346; slow-moving proteinase; erythrocyte membrane aspartic proteinase

NCBI Summary for CTSE

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq]
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UniProt Comments for CTSE

CTSE: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Belongs to the peptidase A1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.34; Protease

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: endosome

Molecular Function: protein homodimerization activity; aspartic-type endopeptidase activity

Biological Process: protein autoprocessing; digestion; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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