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CYLN2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6290382

The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CYLN2, Polyclonal Antibody
Full Product Name
CYLN2, CT (CLIP2, CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4, CAP-Gly domain-containing linker protein 2, Cytoplasmic linker protein 115, Cytoplasmic linker protein 2, Williams-Beuren syndrome chromosomal region 3 protein, Williams-Beuren syndrome chromosomal
Product Gene Name
anti-CYLN2 antibody
Product Synonym Gene Name
CLIP2
Product Synonym Names
CLIP2; CYLN2; KIAA0291; WBSCR3; WBSCR4; WSCR4; CAP-Gly domain-containing linker protein 2; Cytoplasmic linker protein 115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
115,837 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (73703805..73820273). Location: 7q11.23
OMIM
603432
3D Structure
ModBase 3D Structure for Q9UDT6
Immunogen
CYLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 910-940 amino acids from the C-terminal region of human CYLN2.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-CYLN2 antibody

Antibodies; KIAA; orf
Applications Tested/Suitable for anti-CYLN2 antibody
Western Blot (WB), FLISA
Application Notes for anti-CYLN2 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CYLN2 antibody

Rose, J. Phd, et al. Mol. Med. (2010). In press: Olsen, J.V., et al. Cell 127(3):635-648(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006). Cheng, J., et al. Science 308(5725):1149-1154(2005). Evgrafov, O.V., et al. Nat. Genet. 36(6):602-606(2004).

Other Notes

Small volumes of anti-CYLN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYLN2 purchase

MBS6290382 is an antibody targeting CYLN2. Also known as CYLN2, CT (CLIP2, CYLN2, KIAA0291, WBSCR3, WBSCR4, WSCR4, CAP-Gly domain-containing linker protein 2, Cytoplasmic linker protein 115, Cytoplasmic linker protein 2, Williams-Beuren syndrome chromosomal region 3 protein, Williams-Beuren syndrome chromosomal. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CYLN2. It may not necessarily be applicable to this product.

NCBI GI #
116008447
NCBI GeneID
7461
NCBI Accession #
NP_003379.3
NCBI Related Accession #
NP_115797.1
UniProt Primary Accession #
Q9UDT6
UniProt Secondary Accession #
O14527; O43611
UniProt Related Accession #
Q9UDT6
GenBank Nucleotide #
NM_003388.4
NCBI Official Full Name
CAP-Gly domain-containing linker protein 2 isoform 1
NCBI Official Synonym Full Names
CAP-GLY domain containing linker protein 2
NCBI Official Symbol
CLIP2
NCBI Official Synonym Symbols
CLIP; CYLN2; WSCR3; WSCR4; WBSCR3; WBSCR4; CLIP-115
UniProt Protein Name
CAP-Gly domain-containing linker protein 2
UniProt Synonym Protein Names
Cytoplasmic linker protein 115; CLIP-115; Cytoplasmic linker protein 2; Williams-Beuren syndrome chromosomal region 3 protein; Williams-Beuren syndrome chromosomal region 4 protein
UniProt Gene Name
CLIP2
UniProt Synonym Gene Names
CYLN2; KIAA0291; WBSCR3; WBSCR4; WSCR4; CLIP-115
UniProt Entry Name
CLIP2_HUMAN
NCBI Protein Information
CAP-Gly domain-containing linker protein 2; cytoplasmic linker 2; cytoplasmic linker protein 2; cytoplasmic linker protein 115; Williams-Beuren syndrome chromosome region 3; Williams-Beuren syndrome chromosome region 4; williams-Beuren syndrome chromosoma

UniProt Comments for CYLN2

CYLN2: Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations. CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: microtubule associated complex; cytoplasmic microtubule

Molecular Function: microtubule plus-end binding
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Research Articles on CYLN2

1. CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I are the main genes causing the cognitive defects

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CYLN2 antibody

 Disease Name  Pubmed Publications
 Leukemia Antibodies  >1 publications with CYLN2 and Leukemia
 Memory Disorders Antibodies  >1 publications with CYLN2 and Memory Disorders
 Carcinoma Antibodies  >1 publications with CYLN2 and Carcinoma
 Cognition Disorders Antibodies  >1 publications with CYLN2 and Cognition Disorders
 Autoimmune Diseases Antibodies  >1 publications with CYLN2 and Autoimmune Diseases

Organs/Tissues associated with anti-CYLN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with CYLN2 and Muscle
 Connective Tissue Antibodies  >2 publications with CYLN2 and Connective Tissue
 Thyroid Antibodies  >1 publications with CYLN2 and Thyroid
 Vascular Antibodies  >1 publications with CYLN2 and Vascular
 Pancreas Antibodies  >1 publications with CYLN2 and Pancreas
 Brain Antibodies  >1 publications with CYLN2 and Brain
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