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EDG6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6294378

EDG6 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. It participates in endothelial differentiation, and may regulate lymphocyte cell signaling. It is a member of the lysophospholipid/lysosphingolipid receptor family. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EDG6, Polyclonal Antibody
Full Product Name
EDG6, NT (S1PR4, EDG6, Sphingosine 1-phosphate receptor 4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6) (PE)
Product Gene Name
anti-EDG6 antibody
Product Synonym Gene Name
S1PR4
Product Synonym Names
S1PR4; EDG6; Sphingosine 1-phosphate receptor 4; Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human EDG6. Species crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
41 kDa
OMIM
603751
3D Structure
ModBase 3D Structure for O95977
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 8-37 in the N-terminal region of human EDG6, UniProt Accession #Q95977.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-EDG6 antibody

Antibodies; G Protein Receptors
Applications Tested/Suitable for anti-EDG6 antibody
Western Blot (WB), FLISA
Application Notes for anti-EDG6 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-EDG6 antibody

Western Blot analysis in NCI-H292 cell line lysates (35ug/lane) usingMBS6011276. This demonstrates the EDG6 antibody detected the EDG6 protein (arrow).
Rabbit Anti-EDG6 Polyclonal Antibody – Cat# MBS6294378

Western Blot (WB) of anti-EDG6 antibody

Western Blot analysis in mouse spleen tissue lysates (35ug/lane) usingMBS6011276. This demonstrates the EDG6 antibody detected the EDG6 protein (arrow).
Rabbit Anti-EDG6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6294378

Product References and Citations for anti-EDG6 antibody

Contos, J.J., et al., FEBS Lett. 531(1):99-102 (2002). Yamazaki, Y., et al., Biochem. Biophys. Res. Commun. 268(2):583-589 (2000). Graler, M.H., et al., Genomics 53(2):164-169 (1998).

Other Notes

Small volumes of anti-EDG6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDG6 purchase

MBS6294378 is an antibody targeting EDG6. Also known as EDG6, NT (S1PR4, EDG6, Sphingosine 1-phosphate receptor 4, Endothelial differentiation G-protein coupled receptor 6, Sphingosine 1-phosphate receptor Edg-6) (PE). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EDG6. It may not necessarily be applicable to this product.

NCBI GI #
42558945
NCBI GeneID
8698
NCBI Accession #
NP_003766
UniProt Primary Accession #
O95977
UniProt Secondary Accession #
D6W612
UniProt Related Accession #
O95977
NCBI Official Full Name
Sphingosine 1-phosphate receptor 4
NCBI Official Synonym Full Names
sphingosine-1-phosphate receptor 4
NCBI Official Symbol
S1PR4
NCBI Official Synonym Symbols
EDG6; LPC1; S1P4; SLP4
UniProt Protein Name
Sphingosine 1-phosphate receptor 4
UniProt Synonym Protein Names
Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6
UniProt Gene Name
S1PR4
UniProt Synonym Gene Names
EDG6; S1P receptor 4; S1P4
UniProt Entry Name
S1PR4_HUMAN
NCBI Protein Information
sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P receptor Edg-6; endothelial differentiation G-protein coupled receptor 6; endothelial differentiation, G protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothe

NCBI Summary for EDG6

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]
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UniProt Comments for EDG6

S1PR4: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; lipid binding

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; phospholipase C activation; immune response; G-protein signaling, adenylate cyclase activating pathway
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Research Articles on EDG6

1. S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EDG6 antibody

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 Disease Pathway antibodies  Disease Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-EDG6 antibody

 Disease Name  Pubmed Publications
 Skin Neoplasms Antibodies  >1 publications with EDG6 and Skin Neoplasms
 Liver Neoplasms Antibodies  >1 publications with EDG6 and Liver Neoplasms

Organs/Tissues associated with anti-EDG6 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with EDG6 and Lung
 Uterus Antibodies  >1 publications with EDG6 and Uterus
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