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EFNA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9600269

Description: EFNA2 Belongs to the ephrin family. Binds to the receptor tyrosine kinases EPHA3, EPHA4 and EPHA5.Function: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and… More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
EFNA2, Polyclonal Antibody
Full Product Name
EFNA2 Antibody
Product Gene Name
anti-EFNA2 antibody
Product Synonym Names
EFNA 2; efna2; EFNA2_HUMAN; ELF1; Eph related receptor tyrosine kinase ligand 6; EPH-related receptor tyrosine kinase ligand 6; Ephrin-A2; EphrinA2; EPLG6; HEK7 L; HEK7 ligand; HEK7-L; HEK7L; LERK 6; LERK-6; LERK6; Ligand of eph related kinase 6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
EFNA2 antibody detects endogenous levels of total EFNA2
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
EFNA2 peptide (MBS9614822) is used for blocking the activity of EFNA2 antibody (MBS9600269)
Molecular Weight
Observed: 24 kDa
Predicted: 24 kDa
3D Structure
ModBase 3D Structure for O43921
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human EFNA2
Subcellular Location
Cell Membrane
Predicted Cross Reactivity
Pig, Zebrafish, Bovine, Chicken
Similarity
Pig (100%), Zebrafish (82%), Bovine (100%), Chicken (100%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EFNA2 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-EFNA2 antibody
WB: 1:500-1:3000
IF/ICC: 1:100-1:500

Immunofluorescence (IF) of anti-EFNA2 antibody

MBS9600269 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-EFNA2 Polyclonal Antibody – Cat# MBS9600269

Western Blot (WB) of anti-EFNA2 antibody

Western blot analysis on HeLa cell lysate using EFNA2 Antibody, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-EFNA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9600269

Western Blot (WB) of anti-EFNA2 antibody

Western blot analysis of extracts from mouse brain, using EFNA2 Antibody.
Rabbit Anti-EFNA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9600269

Other Notes

Small volumes of anti-EFNA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EFNA2 purchase

MBS9600269 is an antibody targeting EFNA2. Also known as EFNA2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EFNA2. It may not necessarily be applicable to this product.

NCBI GI #
27894381
NCBI GeneID
1943
NCBI Accession #
NP_001396.2
UniProt Primary Accession #
O43921
UniProt Secondary Accession #
O76020
UniProt Related Accession #
O43921
GenBank Nucleotide #
NM_001405.3
NCBI Official Full Name
ephrin-A2
NCBI Official Synonym Full Names
ephrin A2
NCBI Official Symbol
EFNA2
NCBI Official Synonym Symbols
ELF-1; EPLG6; LERK6; HEK7-L; LERK-6
UniProt Protein Name
Ephrin-A2
UniProt Synonym Protein Names
EPH-related receptor tyrosine kinase ligand 6; LERK-6; HEK7 ligand; HEK7-L
Protein Family
Ephrin
UniProt Gene Name
EFNA2
UniProt Synonym Gene Names
EPLG6; LERK6; LERK-6; HEK7-L
NCBI Protein Information
ephrin-A2

NCBI Summary for EFNA2

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]
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UniProt Comments for EFNA2

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis ().
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Research Articles on EFNA2

1. Ephrin-A2 expression was correlated with Ki-67 expression in PCa patients, both at the gene scale and protein level. Our data indicate that Ephrin-A2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate prostate cancer progression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EFNA2 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-EFNA2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with EFNA2 and Inflammation

Organs/Tissues associated with anti-EFNA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with EFNA2 and Bone
 Embryonic Tissue Antibodies  >2 publications with EFNA2 and Embryonic Tissue
 Lung Antibodies  >1 publications with EFNA2 and Lung
 Intestine Antibodies  >1 publications with EFNA2 and Intestine
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