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EFNA4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2561337

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
EFNA4, Polyclonal Antibody
Full Product Name
EFNA4 Polyclonal Antibody
Product Gene Name
anti-EFNA4 antibody
Product Synonym Names
EFL 4; EFL4; EFN A4; EFNA 4; EFNA4; EFNA4; Eph related receptor tyrosine kinase ligand 4; EPH-related receptor tyrosine kinase ligand 4; Ephrin-A4; EphrinA4; EPLG 4; EPLG4; LERK 4; LERK-4; LERK4; Ligand of Eph related kinase 4; MGC125826
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purity/Purification
Antigen Affinity Purification
Concentration
1mg/mL (lot specific)
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
OMIM
601380
3D Structure
ModBase 3D Structure for P52798
Immunogen
Synthetic peptide of human EFNA4
Conjugation
Unconjugated

Product Categories/Family for anti-EFNA4 antibody

Cardiovascular; Developmental Biology; Neuroscience
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EFNA4 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-EFNA4 antibody
IHC: 1:25-1:100
ELISA: 1:5000-1:10000

Immunohistochemistry (IHC) of anti-EFNA4 antibody

Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using EFNA4 Polyclonal Antibody at dilution of 1:25(×200)
Rabbit Anti-EFNA4 Polyclonal Antibody – Cat# MBS2561337

Immunohistochemistry (IHC) of anti-EFNA4 antibody

Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using EFNA4 Polyclonal Antibody at dilution of 1:25(×200)
Rabbit Anti-EFNA4 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2561337

Other Notes

Small volumes of anti-EFNA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EFNA4 purchase

MBS2561337 is an antibody targeting EFNA4. Also known as EFNA4 Polyclonal Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EFNA4. It may not necessarily be applicable to this product.

NCBI GI #
4885197
NCBI GeneID
1945
NCBI Accession #
NP_005218.1
UniProt Primary Accession #
P52798
UniProt Related Accession #
P52798
GenBank Nucleotide #
NP_005218.1
NCBI Official Full Name
ephrin-A4 isoform a
NCBI Official Synonym Full Names
ephrin A4
NCBI Official Symbol
EFNA4
NCBI Official Synonym Symbols
EFL4; EPLG4; LERK4
UniProt Protein Name
Ephrin-A4
UniProt Synonym Protein Names
EPH-related receptor tyrosine kinase ligand 4
Protein Family
Ephrin
UniProt Gene Name
EFNA4
UniProt Synonym Gene Names
EPLG4; LERK4; LERK-4
UniProt Entry Name
EFNA4_HUMAN
NCBI Protein Information
ephrin-A4

UniProt Comments for EFNA4

EFNA4: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. Belongs to the ephrin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; transmembrane-ephrin receptor activity; ephrin receptor binding

Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway; osteoclast differentiation; bone remodeling
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Research Articles on EFNA4

1. Study present for the first time in vitro and in vivo evidence suggesting that the major role of two ephrin A4 isoforms in chronic lymphocytic leukemia could be related with a non-previously described mechanism of survival linked to extravasation strongly dependent on integrin signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EFNA4 antibody

 Reference Product  PubMed Publications
 EPHA2 antibody  >2 publications with EFNA4 and EPHA2
 EPHA4 antibody  >1 publications with EFNA4 and EPHA4

Pathways associated with anti-EFNA4 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with anti-EFNA4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with EFNA4 and Neoplasms
 Immune System Diseases Antibodies  >3 publications with EFNA4 and Immune System Diseases
 Bone Diseases Antibodies  >2 publications with EFNA4 and Bone Diseases
 Nervous System Diseases Antibodies  >1 publications with EFNA4 and Nervous System Diseases
 Chromosome Aberrations Antibodies  >1 publications with EFNA4 and Chromosome Aberrations
 Necrosis Antibodies  >1 publications with EFNA4 and Necrosis
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