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ELL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6295255

MaxLight550 is a new Yellow-Green photostable dye conjugate comparable to Alexa Fluor546, 555, DyLight549, Cy3, TRITC and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (550nm); Emission (575nm); Extinction… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ELL, Polyclonal Antibody
Full Product Name
ELL, CT (ELL, C19orf17, RNA polymerase II elongation factor ELL, Eleven-nineteen lysine-rich leukemia protein) (MaxLight 550)
Product Gene Name
anti-ELL antibody
Product Synonym Names
ELL; C19orf17; RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
68,265 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (18553473..18632937, complement). Location: 19p13.1
OMIM
600284
3D Structure
ModBase 3D Structure for P55199
Immunogen
ELL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-553 amino acids from the C-terminal region of human ELL.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-ELL antibody

Antibodies; Cancer Markers; Leukemia
Applications Tested/Suitable for anti-ELL antibody
Western Blot (WB), FLISA
Application Notes for anti-ELL antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ELL antibody

Liu, L., et al. Prostate 70(7):797-805(2010). Zhou, J., et al. J. Biol. Chem. 284(28):19142-19152(2009). Jiang, F., et al. Cancer Lett. 253(2):265-272(2007). Matsuoka, S., et al. Science 316(5828):1160-1166(2007). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007).

Other Notes

Small volumes of anti-ELL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELL purchase

MBS6295255 is an antibody targeting ELL. Also known as ELL, CT (ELL, C19orf17, RNA polymerase II elongation factor ELL, Eleven-nineteen lysine-rich leukemia protein) (MaxLight 550). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ELL. It may not necessarily be applicable to this product.

NCBI GI #
5729812
NCBI GeneID
8178
NCBI Accession #
NP_006523.1
UniProt Primary Accession #
P55199
UniProt Related Accession #
P55199
GenBank Nucleotide #
NM_006532.3
NCBI Official Full Name
RNA polymerase II elongation factor ELL
NCBI Official Synonym Full Names
elongation factor RNA polymerase II
NCBI Official Symbol
ELL
NCBI Official Synonym Symbols
MEN; ELL1; PPP1R68; C19orf17
UniProt Protein Name
RNA polymerase II elongation factor ELL
UniProt Synonym Protein Names
Eleven-nineteen lysine-rich leukemia protein
Protein Family
RNA polymerase II elongation factor
UniProt Gene Name
ELL
UniProt Synonym Gene Names
C19orf17
UniProt Entry Name
ELL_HUMAN
NCBI Protein Information
RNA polymerase II elongation factor ELL; ELL gene (11-19 lysine-rich leukemia gene); eleven-nineteen lysine-rich leukemia protein; protein phosphatase 1, regulatory subunit 68

UniProt Comments for ELL

ELL: Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with MLL/HRX. The result is a rogue activator protein. Belongs to the ELL/occludin family.

Protein type: Transcription initiation complex; Nuclear receptor co-regulator; Oncoprotein

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; Cajal body; transcription elongation factor complex; nuclear speck

Molecular Function: protein binding; phosphatase binding

Biological Process: transcription from RNA polymerase II promoter; viral reproduction; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of viral transcription; in utero embryonic development; positive regulation of RNA elongation; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase III promoter; gene expression; snRNA transcription from RNA polymerase III promoter
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Research Articles on ELL

1. Studies indicate that the super elongation complex (SEC) consisting of ELL, P-TEFb (CDK9) and MLL required for rapid transcriptional induction in the presence or absence of paused RNA polymerase II (Pol II).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ELL antibody

 Reference Product  PubMed Publications
 EAF2 antibody  >20 publications with ELL and EAF2
 EAF1 antibody  >14 publications with ELL and EAF1
 SNF8 antibody  >3 publications with ELL and SNF8
 TFPT antibody  >1 publications with ELL and TFPT

Pathways associated with anti-ELL antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex In The Absence Of HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex In The Absence Of HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 HIV-1 Transcription Elongation Pathway antibodies  HIV-1 Transcription Elongation Pathway Diagram
 HIV-1 Elongation Arrest And Recovery Pathway antibodies  HIV-1 Elongation Arrest And Recovery Pathway Diagram
 Late Phase Of HIV Life Cycle Pathway antibodies  Late Phase Of HIV Life Cycle Pathway Diagram

Diseases associated with anti-ELL antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >140 publications with ELL and Cardiovascular Diseases
 Heart Diseases Antibodies  >84 publications with ELL and Heart Diseases
 Brain Diseases Antibodies  >79 publications with ELL and Brain Diseases
 Hemorrhage Antibodies  >40 publications with ELL and Hemorrhage
 Neoplasm Metastasis Antibodies  >35 publications with ELL and Neoplasm Metastasis
 Kidney Diseases Antibodies  >34 publications with ELL and Kidney Diseases
 Drug Toxicity Antibodies  >18 publications with ELL and Drug Toxicity
 Necrosis Antibodies  >14 publications with ELL and Necrosis
 Inflammation Antibodies  >14 publications with ELL and Inflammation
 Cholestasis Antibodies  >13 publications with ELL and Cholestasis

Organs/Tissues associated with anti-ELL antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >214 publications with ELL and Brain
 Blood Antibodies  >163 publications with ELL and Blood
 Esophagus Antibodies  >108 publications with ELL and Esophagus
 Heart Antibodies  >85 publications with ELL and Heart
 Bone Antibodies  >84 publications with ELL and Bone
 Liver Antibodies  >71 publications with ELL and Liver
 Lung Antibodies  >66 publications with ELL and Lung
 Intestine Antibodies  >58 publications with ELL and Intestine
 Vascular Antibodies  >52 publications with ELL and Vascular
 Lymph Antibodies  >52 publications with ELL and Lymph
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